Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500614 | 1.00 | PAOX (0.35) | PAOXMTNR1AMTNR1BKDM4EADRA1A | |
| SCHEMBL5496105 | 0.91 | PAOX (0.37) | PAOXMTNR1AMTNR1BKDM4EADRA1A | |
| SCHEMBL5502978 | 0.90 | ABCB1 (0.41) | PAOXFOLH1MAPTSMN1; SMN2ZDHHC7 | |
| SCHEMBL5884046 | 0.87 | KDM4E (0.35) | PAOXMTNR1AMTNR1BKDM4EADRA1A | |
| SCHEMBL5499942 | 0.86 | MTNR1A (0.34) | MTNR1AMTNR1BKDM4EADRA1AMAPK1 | |
| SCHEMBL5499259 | 0.86 | MTNR1A (0.34) | PAOXMTNR1AMTNR1BKDM4EADRA1A | |
| SCHEMBL5494606 | 0.86 | MTNR1A (0.34) | MTNR1AMTNR1BKDM4EADRA1AMAPK1 | |
| SCHEMBL7069371 | 0.86 | MEN1 (0.39) | MTNR1AMTNR1BADRA1ACHRM1AKR1A1 | |
| SCHEMBL4846865 | 0.86 | MEN1 (0.39) | MTNR1AMTNR1BADRA1ACHRM1AKR1A1 | |
| SCHEMBL6413955 | 0.86 | MEN1 (0.39) | MTNR1AMTNR1BADRA1ACHRM1AKR1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7413878-B2 | Recombinant host cells expressing atoAD and capable of making a polyketide using a starter unit | KOSAN BIOSCIENCES, INC. (US) | 2008-08-19 | — | — | US | disclosed |
| US-RE39836-E1 | Macrolide antinfective agents | KOSAN BIOSCIENCES, INC. (US) | 2007-09-11 | — | — | US | disclosed |
| EP-1754700-A2 | Synthesis of oligoketides | Kosan Biosciences, Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-1171446-B1 | MACROLIDE ANTIINFECTIVE AGENTS | KOSAN BIOSCIENCES INC (US) | 2006-09-20 | — | — | EP | disclosed |
| US-7067290-B2 | Method for production of polyketides | KOSAN BIOSCIENCES INCORPORATED (US) | 2006-06-27 | — | — | US | disclosed |
| US-7022825-B2 | Polyketides and antibiotics | KOSAN BIOSCIENCES, INC. (US) | 2006-04-04 | — | — | US | disclosed |
| US-6794366-B2 | ERYTHRONOLIDE DERIVATIVES THAT CONTAIN MODIFICATIONS FROM THE NATIVE STRUCTURE AT POSITIONS 13, E.G., 15-(QUINOL-4-YL-ACETAMIDOERYTHROMYCIN A; BACTERICIDES; PRESERVATIVES | KOSAN BIOSCIENCES, INC. | 2004-09-21 | — | — | US | disclosed |
| US-6762168-B2 | ANTIBACTERIAL COMPOUNDS. THE INVENTION CONCERNS MACROLIDE ANTIBIOTICS USEFUL AS ANTIINFECTIVE AGENTS. | KOSAN BIOSCIENCES, INC. | 2004-07-13 | — | — | US | disclosed |
| US-20040096946-A1 | Metabolic pathways for starter units in polyketide biosynthesis | KOSAN BIOSCIENCES, INC. | 2004-05-20 | — | — | US | disclosed |
| WO-2004007688-A2 | METABOLIC PATHWAYS FOR STARTER UNITS IN POLYKETIDE BIOSYNTHESIS | KOSAN BIOSCIENCES, INC. (US) | 2004-01-22 | — | — | WO | disclosed |
| US-20020156028-A1 | Macrolide antiinfective agents | CHU DANIEL T W (US) | 2002-10-24 | — | — | US | disclosed |
| US-6458771-B1 | SERIES OF KETOLIDE ANTIBACTERIALS IN THE MACROLIDE FAMILY, DRUGS AND INTERMEDIATES, ERYTHROMYCIN ANALOGUES USEFUL IN THE TREATMENT OF BACTERIAL AND PROTOZOAL INFECTIONS AND IN THE TREATMENT OF GASTRIC MOTILITY | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-10-01 | — | — | US | disclosed |
| US-6451768-B1 | Macrolide antiinfective agents | KOSAN BIOSCIENCES, INC. | 2002-09-17 | — | — | US | disclosed |
| US-20020119938-A1 | Macrolide antiinfective agents | CHU DANIEL (US) | 2002-08-29 | — | — | US | disclosed |
| US-6395710-B1 | CONTROLLING INFECTIONS | KOSAN BIOSCIENCES, INC. | 2002-05-28 | — | — | US | disclosed |
| US-20020055472-A1 | Macrolide antiinfective agents | KOSAN BIOSCIENCES, INC. | 2002-05-09 | — | — | US | disclosed |
| EP-1171446-A2 | MACROLIDE ANTIINFECTIVE AGENTS | Kosan Biosciences, Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| EP-1171448-A2 | MACROLIDE ANTIINFECTIVE AGENTS | Kosan Biosciences, Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000063224-A2 | MACROLIDE ANTIINFECTIVE AGENTS | KOSAN BIOSCIENCES, INC. (US) | 2000-10-26 | — | — | WO | disclosed |
| WO-2000063225-A2 | MACROLIDE ANTIINFECTIVE AGENTS | KOSAN BIOSCIENCES, INC. (US) | 2000-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156028-A1 | Macrolide antiinfective agents | DOHH, MRPS18B, MRPL21 | PAOX 3653/4885MTNR1A 2634/4885MTNR1B 1839/4885 |
| US-20020119938-A1 | Macrolide antiinfective agents | MLNR, DOHH, NOP2 | PAOX 1848/4885MTNR1A 198/4885MTNR1B 380/4885 |
| US-20020055472-A1 | Macrolide antiinfective agents | BECN1, HSPA5, SQSTM1 | PAOX 1963/4885MTNR1A 872/4885MTNR1B 882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.