Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 4/20 | 0.34 |
| ▸ | IDH2 | P48735 | 3/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4819631 | 0.95 | IDH1 (0.36) | ALDH1A1IDH1IDH2KMT2AMBOAT4 | |
| SCHEMBL4819838 | 0.92 | ALDH1A1 (0.34) | ALDH1A1LMNAPDE2ACRHR1KMT2A | |
| SCHEMBL8390372 | 0.91 | ALDH1A1 (0.38) | ALDH1A1KMT2AMEN1GAAENPP1 | |
| SCHEMBL7262159 | 0.89 | LMNA (0.39) | ALDH1A1LMNAPDE2ACRHR1KMT2A | |
| SCHEMBL4483453 | 0.87 | ALDH1A1 (0.37) | ALDH1A1LMNACRHR1KMT2AMBOAT4 | |
| SCHEMBL5936228 | 0.85 | CRHR1 (0.38) | ALDH1A1LMNAPDE2ACRHR1KMT2A | |
| SCHEMBL14596578 | 0.85 | KMT2A (0.37) | ALDH1A1CRHR1KMT2AMBOAT4MEN1 | |
| SCHEMBL4820872 | 0.85 | ALDH1A1 (0.38) | ALDH1A1LMNAIDH1IDH2PDE2A | |
| SCHEMBL6995709 | 0.85 | LMNA (0.35) | ALDH1A1LMNAKMT2AMBOAT4MEN1 | |
| SCHEMBL976390 | 0.84 | MAPK1 (0.35) | ALDH1A1KMT2AMBOAT4MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329663-B2 | Substituted-triazolopyrimidines as anticancer agents | WYETH (US) | 2008-02-12 | — | — | US | claimed |
| US-20020068744-A1 | Substituted-triazolopyrimidines as anticancer agents | AMERICAN HOME PRODUCTS CORPORATION | 2002-06-06 | — | — | US | claimed |
| US-7329663-B2 | Substituted-triazolopyrimidines as anticancer agents | WYETH (US) | 2008-02-12 | — | — | US | disclosed |
| EP-1307200-A2 | SUBSTITUTED-TRIAZOLOPYRIMIDINES AS ANTICANCER AGENTS | Wyeth (US) | 2003-05-07 | — | — | EP | disclosed |
| US-20020068744-A1 | Substituted-triazolopyrimidines as anticancer agents | AMERICAN HOME PRODUCTS CORPORATION | 2002-06-06 | — | — | US | disclosed |
| WO-2002002563-A2 | SUBSTITUTED-TRIAZOLOPYRIMIDINES AS ANTICANCER AGENTS | WYETH (US) | 2002-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020068744-A1 | Substituted-triazolopyrimidines as anticancer agents | TUBB3, TUBA1C, TUBB1 | ALDH1A1 2231/4885LMNA 2723/4885IDH1 733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.