SCHEMBL976390

SCHEMBL976390

CC(Nc1c(-c2c(F)cc(F)cc2F)c(Cl)nc2ncnn12)C(F)(F)F

nearest known ligand 0.35

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.35
KMT2A Q03164 2/20 0.34
MEN1 O00255 1/20 0.34
GAA P10253 1/20 0.34
ALDH1A1 P00352 4/20 0.34
TSHR P16473 2/20 0.34
POLB P06746 1/20 0.34
KDM4E B2RXH2 2/20 0.33
HPGD P15428 1/20 0.33
MBOAT4 Q96T53 3/20 0.32
ALOX15 P16050 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL343322 1.00 MAPK1 (0.35) MAPK1KMT2AMEN1GAAALDH1A1
SCHEMBL4818612 1.00 MAPK1 (0.35) MAPK1KMT2AMEN1GAAALDH1A1
SCHEMBL14596578 0.95 KMT2A (0.37) MAPK1KMT2AMEN1GAAALDH1A1
SCHEMBL4821470 0.91 ALDH1A1 (0.33) MAPK1KMT2AMEN1GAAALDH1A1
SCHEMBL14582398 0.91 ALDH1A1 (0.33) MAPK1KMT2AMEN1GAAALDH1A1
SCHEMBL23925419 0.91 ALDH1A1 (0.33) MAPK1KMT2AMEN1GAAALDH1A1
SCHEMBL23925421 0.91 ALDH1A1 (0.33) MAPK1KMT2AMEN1GAAALDH1A1
SCHEMBL977522 0.91 MAPK1 (0.35) MAPK1KMT2AMEN1GAAALDH1A1
SCHEMBL3117730 0.91 MAPK1 (0.35) MAPK1KMT2AMEN1GAAALDH1A1
SCHEMBL80486 0.91 MAPK1 (0.35) MAPK1KMT2AMEN1GAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090149455-A1 Use of Triazolopyrimidines for Controlling Plant Diseases on Legumes BAYER CROPSCIENCE AG (DE) 2009-06-11 US claimed
US-7329663-B2 Substituted-triazolopyrimidines as anticancer agents WYETH (US) 2008-02-12 US claimed
US-6699855-B2 PYRROLOPYRAZINONES USEFUL AS SERINE PROTEASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2004-03-02 US claimed
US-6699874-B2 SURFACE ACTIVE AGENT AND SYNERGISTICALLY EFFECTIVE AMOUNTS OFAN AZOLOPYRIMIDINE BASF AKTIENGESELLSCHAFT (DE) 2004-03-02 US claimed
US-6656944-B2 Synergistc mixtures BASF AKTIENGESELLSCHAFT (DE) 2003-12-02 US claimed
US-20030206968-A1 Fungicidal mixtures COTTER HENRY VAN TUYL (US) 2003-11-06 US claimed
EP-1307200-A2 SUBSTITUTED-TRIAZOLOPYRIMIDINES AS ANTICANCER AGENTS Wyeth (US) 2003-05-07 EP claimed
US-6518275-B1 Fungicidal mixtures BASF AKTIENGESELLSCHAFT (DE) 2003-02-11 US claimed
US-20020111380-A1 Fungicidal mixtures BASF AKTIENGESELLSCHAFT (DE) 2002-08-15 US claimed
US-20020068744-A1 Substituted-triazolopyrimidines as anticancer agents AMERICAN HOME PRODUCTS CORPORATION 2002-06-06 US claimed
US-20020065248-A1 Inhibitors of hepatitis C virus NS3 protease BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-05-30 US claimed
US-20020045631-A1 Enhancement of the efficacy of triazolopyrimidines INTELLECTUAL PROPERTY DEPARTMENT, BASF AKTIENGESELLSCHAFT (DE) 2002-04-18 US claimed
WO-2002002563-A2 SUBSTITUTED-TRIAZOLOPYRIMIDINES AS ANTICANCER AGENTS WYETH (US) 2002-01-10 WO claimed
US-6277856-B1 SYNERGISTIC MIXTURE COMPRISING AN AZOLOPYRIMIDINE DERIVATIVE AND A SYNTHETIC STROBILURINE DERIVATIVE IN A CARRIER TO CONTROL GROWTH OF PHYTOPATHOGENIC FUNGI AMERICAN CYNAMID CO. 2001-08-21 US claimed
US-6268371-B1 Fungicidal mixtures AMERICAN CYANAMID CO. 2001-07-31 US claimed
EP-0988790-A1 Fungicidal mixtures American Cyanamid Company (US) 2000-03-29 EP claimed
EP-4653442-A1 POLYCYCLIC COMPOUND FOR TREATING NEUROLOGICAL DISEASES AND TUMORS SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) 2025-11-26 EP disclosed
WO-2024153202-A1 POLYCYCLIC COMPOUND FOR TREATING NEUROLOGICAL DISEASES AND TUMORS 中国科学院上海有机化学研究所 2024-07-25 WO disclosed
EP-0988790-A1 Fungicidal mixtures American Cyanamid Company (US) 2000-03-29 EP disclosed
EP-0943241-A1 Enhancement of the efficacy of triazolopyrimidines American Cyanamid Company (US) 1999-09-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030206968-A1 Fungicidal mixtures DDT, TPMT, CYP2D6 MAPK1 3124/4885KMT2A 2128/4885MEN1 196/4885
US-20020111380-A1 Fungicidal mixtures TYR, MAOA, PMM2 MAPK1 2595/4885KMT2A 522/4885MEN1 599/4885
US-20020065248-A1 Inhibitors of hepatitis C virus NS3 protease TMPRSS15, CTRC, CPN1 MAPK1 1202/4885KMT2A 3703/4885MEN1 3394/4885
US-20020068744-A1 Substituted-triazolopyrimidines as anticancer agents TUBB3, TUBA1C, TUBB1 MAPK1 916/4885KMT2A 2012/4885MEN1 2807/4885
US-20090149455-A1 Use of Triazolopyrimidines for Controlling Plant Diseases on Legumes TYMP, CCNT2, PNPO MAPK1 1694/4885KMT2A 1970/4885MEN1 4431/4885
US-20020045631-A1 Enhancement of the efficacy of triazolopyrimidines EPX, CYP2E1, PTPN3 MAPK1 2299/4885KMT2A 3027/4885MEN1 1452/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.