Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044753 | 0.83 | L3MBTL1 (0.47) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2PDK1 | |
| SCHEMBL15104669 | 0.79 | RAB9A (0.46) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2EGFR | |
| SCHEMBL374899 | 0.77 | KMT2A (0.46) | KDM4EL3MBTL1SMN1; SMN2EGFRERBB2 | |
| SCHEMBL6902503 | 0.77 | MAPT (0.42) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2EGFR | |
| SCHEMBL26674772 | 0.77 | CA2 (0.41) | KDM4EL3MBTL1ALDH1A1CA2CA12 | |
| SCHEMBL2077257 | 0.77 | SLC40A1 (0.49) | KDM4ESLC40A1ALDH1A1PDK1PDK2 | |
| SCHEMBL7908594 | 0.75 | LMNA (0.48) | L3MBTL1ALDH1A1SMN1; SMN2PDK1PDK2 | |
| SCHEMBL18489422 | 0.73 | TGM2 (0.46) | EGFRERBB2 | |
| SCHEMBL27742417 | 0.73 | GAA (0.45) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2EGFR | |
| SCHEMBL29476654 | 0.73 | METAP1 (0.46) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973886-A2 | PROKINETICIN 1 RECEPTOR ANTAGONISTS | Janssen Pharmaceutica, N.V. (BE) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007079163-A2 | PROKINETICIN 1 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-12 | — | — | WO | disclosed |