SCHEMBL482183

SCHEMBL482183

Cc1cc(C)c(Br)cc1O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 3/20 0.48
ALOX12 P18054 2/20 0.48
CYP3A4 P08684 2/20 0.48
KDM4E B2RXH2 1/20 0.48
ALDH1A1 P00352 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP2D6 P10635 1/20 0.48
MAPT P10636 1/20 0.48
G6PD P11413 1/20 0.48
CYP2C9 P11712 1/20 0.48
PKM P14618 1/20 0.48
HPGD P15428 1/20 0.48
MAPK1 P28482 1/20 0.48
CYP2C19 P33261 1/20 0.48
CCR6 P51684 1/20 0.48
HIF1A Q16665 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
HSD17B10 Q99714 1/20 0.48
TDP1 Q9NUW8 2/20 0.40
TP53 P04637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30283411 1.00 ALOX15 (0.48) ALOX15ALOX12CYP3A4KDM4EALDH1A1
SCHEMBL282020 0.89 ALOX15 (0.55) ALOX15ALOX12CYP3A4KDM4EALDH1A1
SCHEMBL23230056 0.86 ALOX15 (0.50) ALOX15ALOX12CYP3A4KDM4EALDH1A1
SCHEMBL68996 0.86 ALOX15 (0.43) ALOX15ALOX12CYP3A4KDM4EALDH1A1
SCHEMBL29446755 0.83 ALOX15 (0.55) ALOX15ALOX12CYP3A4KDM4EALDH1A1
SCHEMBL1146850 0.83 ALOX15 (0.55) ALOX15ALOX12CYP3A4KDM4EALDH1A1
SCHEMBL6743198 0.83 ALOX15 (0.40) ALOX15ALOX12CYP3A4KDM4EALDH1A1
SCHEMBL30573016 0.79 ALDH1A1 (0.46) ALOX15ALOX12CYP3A4KDM4EALDH1A1
SCHEMBL18262903 0.79 ALDH1A1 (0.46) ALOX15ALOX12CYP3A4KDM4EALDH1A1
SCHEMBL47929 0.78 ALDH1A1 (0.61) ALOX15ALOX12CYP3A4KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4301736-B1 MACROCYCLIC COMPOUNDS AS PROTEASOME SUBUNIT BETA TYPE-5 INHIBITORS LEAD DISCOVERY CENTER GMBH (DE) 2025-10-08 EP disclosed
EP-4511114-A1 HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN Vertex Pharmaceuticals Incorporated (US) 2025-02-26 EP disclosed
US-20240415819-A1 MACROCYCLIC COMPOUNDS AS PROTEASOME SUBUNIT BETA TYPE-5 INHIBITORS QLi5 Therapeutics AG (DE) 2024-12-19 US disclosed
CN-118251383-A Macrocyclic compounds as proteasome beta subunit type 5 inhibitors 利德探索中心有限公司 2024-06-25 CN disclosed
WO-2024023585-A2 UROLITHIN DERIVATIVES AND THERAPEUTIC USES VANDRIA SA (CH) 2024-02-01 WO disclosed
EP-4301736-A1 MACROCYCLIC COMPOUNDS AS PROTEASOME SUBUNIT BETA TYPE-5 INHIBITORS Lead Discovery Center GmbH (DE) 2024-01-10 EP disclosed
US-20230382910-A1 HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN VERTEX PHARMACEUTICALS INCORPORATED 2023-11-30 US disclosed
US-20230382910-A1 HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN VERTEX PHARMACEUTICALS INCORPORATED 2023-11-30 US disclosed
US-20230382910-A1 HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN VERTEX PHARMACEUTICALS INCORPORATED 2023-11-30 US disclosed
WO-2023205778-A1 HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-10-26 WO disclosed
US-9227978-B2 Covalent inhibitors of Kras G12C ARAXES PHARMA LLC (US) 2016-01-05 US disclosed
US-20140288045-A1 COVALENT INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2014-09-25 US disclosed
EP-2757113-A2 Catalysts, processes for making catalysts, processes for making polyolefin compositions and polyolefin compositions Dow Global Technologies LLC (US) 2014-07-23 EP disclosed
US-8592615-B2 Catalysts, processes for making catalysts, processes for making polyolefin compositions, and polyolefin compositions DOW GLOBAL TECHNOLOGIES, LLC (US) 2013-11-26 US disclosed
EP-2411424-A2 CATALYSTS, PROCESSES FOR MAKING CATALYSTS, PROCESSES FOR MAKING POLYOLEFIN COMPOSITIONS AND POLYOLEFIN COMPOSITIONS Dow Global Technologies LLC (US) 2012-02-01 EP disclosed
WO-2010102163-A2 CATALYSTS, PROCESSES FOR MAKING CATALYSTS, PROCESSES FOR MAKING POLYOLEFIN COMPOSITIONS AND POLYOLEFIN COMPOSITIONS DOW GLOBAL TECHNOLOGIES INC. (US) 2010-09-10 WO disclosed
WO-2010102163-A2 CATALYSTS, PROCESSES FOR MAKING CATALYSTS, PROCESSES FOR MAKING POLYOLEFIN COMPOSITIONS AND POLYOLEFIN COMPOSITIONS DOW GLOBAL TECHNOLOGIES INC. (US) 2010-09-10 WO disclosed
US-20100227990-A1 CATALYSTS, PROCESSES FOR MAKING CATALYSTS, PROCESSES FOR MAKING POLYOLEFIN COMPOSITIONS, AND POLYOLEFIN COMPOSITIONS DOW GLOBAL TECHNOLOGIES INC. (US) 2010-09-09 US disclosed
US-20100227990-A1 CATALYSTS, PROCESSES FOR MAKING CATALYSTS, PROCESSES FOR MAKING POLYOLEFIN COMPOSITIONS, AND POLYOLEFIN COMPOSITIONS DOW GLOBAL TECHNOLOGIES INC. (US) 2010-09-09 US disclosed
US-20100227990-A1 CATALYSTS, PROCESSES FOR MAKING CATALYSTS, PROCESSES FOR MAKING POLYOLEFIN COMPOSITIONS, AND POLYOLEFIN COMPOSITIONS DOW GLOBAL TECHNOLOGIES INC. (US) 2010-09-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140288045-A1 COVALENT INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS ALOX15 4571/4885ALOX12 4450/4885CYP3A4 4548/4885
US-20100227990-A1 CATALYSTS, PROCESSES FOR MAKING CATALYSTS, PROCESSES FOR MAKING POLYOLEFIN COMPOSITIONS, AND POLYOLEFIN COMPOSITIONS FDFT1, PARG, CPSF6 ALOX15 58/4885ALOX12 85/4885CYP3A4 1739/4885
US-20230382910-A1 HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN TRPV1, SCN3A, KCNN3 ALOX15 694/4885ALOX12 804/4885CYP3A4 685/4885
US-20240415819-A1 MACROCYCLIC COMPOUNDS AS PROTEASOME SUBUNIT BETA TYPE-5 INHIBITORS PSMB5, PSMA5, PSMB1 ALOX15 1921/4885ALOX12 3166/4885CYP3A4 2462/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.