Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.59 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.59 |
| ▸ | TUBB | P07437 | 5/20 | 0.59 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.59 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.59 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.59 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.59 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.59 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.59 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.59 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.59 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.59 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.59 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.59 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.59 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21845093 | 0.87 | TUBB4A (0.60) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4818613 | 0.87 | MAPT (0.53) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4821487 | 0.87 | MAPT (0.63) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL9726919 | 0.85 | MAPT (0.58) | TUBB1 | |
| SCHEMBL7367549 | 0.84 | MAPT (0.50) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6899973 | 0.84 | TUBB4A (0.50) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL19003369 | 0.84 | TUBB1 (0.50) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Hydroxyphenstatin SCHEMBL13197632 | 0.83 | KDM4E (0.67) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Hydroxyphenstatin SCHEMBL30910835 | 0.83 | KDM4E (0.67) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| 3,4,5-Trimethoxybenzoic Acid SCHEMBL2327557 | 0.83 | TPMT (0.58) | TUBB1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11639325-B2 | Compositions of polyhydroxylated benzophenones and methods of treatment of neurodegenerative disorders | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2023-05-02 | — | — | US | disclosed |
| US-11180438-B2 | Compositions of polyhydroxylated benzophenones and methods of treatment of neurodegenerative disorders | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2021-11-23 | — | — | US | disclosed |
| US-20210171429-A1 | COMPOSITIONS OF POLYHYDROXYLATED BENZOPHENONES AND METHODS OF TREATMENT OF NEURODEGENERATIVE DISORDERS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2021-06-10 | — | — | US | disclosed |
| US-20200087236-A9 | COMPOSITIONS OF POLYHYDROXYLATED BENZOPHENONES AND METHODS OF TREATMENT OF NEURODEGENERATIVE DISORDERS | THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL (US) | 2020-03-19 | — | — | US | disclosed |
| US-7470723-B2 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| US-20080114061-A1 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION | 2008-05-15 | — | — | US | disclosed |
| US-7312241-B2 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION (US) | 2007-12-25 | — | — | US | disclosed |
| CN-101056846-A | Diphenylethylene compounds and uses thereof | CELGENE CORP (US) | 2007-10-17 | — | — | CN | disclosed |
| CN-101053558-A | Diphenylethylene compounds and uses thereof | CELGENE CORP (US) | 2007-10-17 | — | — | CN | disclosed |
| EP-1799634-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2007-06-27 | — | — | EP | disclosed |
| CN-1780811-A | Diphenylethylene compounds and uses thereof | CELGENE CORP (US) | 2006-05-31 | — | — | CN | disclosed |
| WO-2006026747-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2006-03-09 | — | — | WO | disclosed |
| EP-1603864-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2005-12-14 | — | — | EP | disclosed |
| US-20050107339-A1 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION | 2005-05-19 | — | — | US | disclosed |
| US-20050014727-A1 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION | 2005-01-20 | — | — | US | disclosed |
| WO-2004078144-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2004-09-16 | — | — | WO | disclosed |
| US-6777578-B2 | INHIBITOR OF TUBULIN POLYMERIZATION; ANTINEOPLASTIC ACTIVITY | ARIZONA BOARD OF REGENTS | 2004-08-17 | — | — | US | disclosed |
| US-20030220304-A1 | Hydroxyphenstatin and the prodrugs thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-11-27 | — | — | US | disclosed |
| WO-1997007790-A9 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF INFECTIOUS DISEASES | — | 1997-09-25 | — | — | WO | disclosed |
| WO-1997007790-A1 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF INFECTIOUS DISEASES | INTERLAB CORPORATION (US) | 1997-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107339-A1 | Diphenylethylene compounds and uses thereof | VHL, TNF, PTGES | TUBB1 3121/4885TUBB4A 2850/4885TUBB 3365/4885 |
| US-20030220304-A1 | Hydroxyphenstatin and the prodrugs thereof | TK1, TUBB8, PHPT1 | TUBB1 7/4885TUBB4A 25/4885TUBB 9/4885 |
| US-11639325-B2 | Compositions of polyhydroxylated benzophenones and methods of treatment of neurodegenerative disorders | HDAC1, HDAC10, HDAC6 | TUBB1 643/4885TUBB4A 599/4885TUBB 605/4885 |
| US-11180438-B2 | Compositions of polyhydroxylated benzophenones and methods of treatment of neurodegenerative disorders | HDAC1, HDAC10, HDAC6 | TUBB1 643/4885TUBB4A 599/4885TUBB 605/4885 |
| US-20200087236-A9 | COMPOSITIONS OF POLYHYDROXYLATED BENZOPHENONES AND METHODS OF TREATMENT OF NEURODEGENERATIVE DISORDERS | HDAC1, HDAC10, HDAC6 | TUBB1 643/4885TUBB4A 599/4885TUBB 605/4885 |
| US-20210171429-A1 | COMPOSITIONS OF POLYHYDROXYLATED BENZOPHENONES AND METHODS OF TREATMENT OF NEURODEGENERATIVE DISORDERS | HDAC1, HDAC10, HDAC6 | TUBB1 643/4885TUBB4A 599/4885TUBB 605/4885 |
| US-20080114061-A1 | Diphenylethylene compounds and uses thereof | VHL, TNF, PTGES | TUBB1 3121/4885TUBB4A 2850/4885TUBB 3365/4885 |
| US-20050014727-A1 | Diphenylethylene compounds and uses thereof | VHL, TNF, PTGES | TUBB1 3121/4885TUBB4A 2850/4885TUBB 3365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.