SCHEMBL4827396

SCHEMBL4827396

CC(=O)NN1C(=O)CCCC1=O.c1cc2cc-2c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.43
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
POLB P06746 1/20 0.38
KDM4E B2RXH2 3/20 0.37
ALDH1A1 P00352 3/20 0.37
HPGD P15428 2/20 0.37
HSD17B10 Q99714 1/20 0.37
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
CYP2C9 P11712 2/20 0.35
CYP2C19 P33261 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
SLC6A3 Q01959 1/20 0.35
BAZ2B Q9UIF8 1/20 0.34
NQO2 P16083 1/20 0.34
PRKDC P78527 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6388210 0.84 NPC1 (0.44) GAANPC1RAB9AL3MBTL1POLB
SCHEMBL8883980 0.84 ALDH1A1 (0.35) GAANPC1RAB9AL3MBTL1POLB
SCHEMBL7524003 0.80 NPC1 (0.36) GAANPC1RAB9AL3MBTL1POLB
SCHEMBL6542130 0.79 NPC1 (0.41) GAANPC1RAB9AL3MBTL1POLB
SCHEMBL10545379 0.77 MEN1 (0.40) GAANPC1RAB9AL3MBTL1POLB
SCHEMBL8883410 0.77 KDM4E (0.38) RAB9APOLBKDM4EALDH1A1CYP11B2
SCHEMBL16327606 0.76 L3MBTL1 (0.47) GAANPC1RAB9AL3MBTL1POLB
SCHEMBL27412940 0.73 HTT (0.49) GAAPOLBKDM4EALDH1A1CYP3A4
SCHEMBL10884861 0.72 ALDH1A1 (0.35) GAAKDM4EALDH1A1HPGDHSD17B10
SCHEMBL8019417 0.71 KDM4E (0.38) GAAKDM4EALDH1A1HPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7427619-B2 Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy BURZYNSKI STANISLAW R 2008-09-23 US claimed
EP-1450781-B1 FORMULATION OF AMINO ACIDS AND RIBOFLAVIN USEFUL TO REDUCE TOXIC EFFECTS OF CYTOTOXIC CHEMOTHERAPY BURZYNSKI STANISLAW R (US) 2006-06-21 EP claimed
EP-0906088-B1 LIPOSOMAL ANTINEOPLASTON THERAPIES WITH MARKEDLY IMPROVED ANTINEOPLASTIC ACTIVITY BURZYNSKI STANISLAW R (US) 2005-11-23 EP claimed
US-20050182064-A1 Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy BURZYNSKI STANISLAW R (US) 2005-08-18 US claimed
EP-1450781-A1 FORMULATION OF AMINO ACIDS AND RIBOFLAVIN USEFUL TO REDUCE TOXIC EFFECTS OF CYTOTOXIC CHEMOTHERAPY Burzynski, Stanislaw R. (US) 2004-09-01 EP claimed
WO-2003045372-A1 FORMULATION OF AMINO ACIDS AND RIBOFLAVIN USEFUL TO REDUCE TOXIC EFFECTS OF CYTOTOXIC CHEMOTHERAPY BURZYNSKI STANISLAW R (US) 2003-06-05 WO claimed
US-20030105104-A1 Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy BURZYNSKI STANISLAW R (US) 2003-06-05 US claimed
EP-0197358-B1 TOPICAL USE OF 3-PHENYLACETYLAMINO-2,6-PIPERIDINEDIONE FOR TREATMENT OF SKIN WRINKLES AND HYPERPIGMENTATION BURZYNSKI, Stanislaw R. (US) 1990-05-23 EP claimed
EP-0197358-A2 Topical use of 3-phenylacetylamino-2,6-piperidinedione for treatment of skin wrinkles and hyperpigmentation BURZYNSKI, Stanislaw R. (US) 1986-10-15 EP claimed
US-4593038-A Applying to skin BURZYNSKI STANISLAW R 1986-06-03 US claimed
EP-4731792-A2 COMPOSITIONS COMPRISING ANTINEOPLASTONS AND METHODS OF TREATING LUNG CANCER Burzynski, Stanislaw R. (US) 2026-04-29 EP disclosed
EP-4731793-A2 COMPOSITIONS COMPRISING ANTINEOPLASTONS AND METHODS OF TREATING PANCREATIC CANCER Burzynski, Stanislaw R. (US) 2026-04-29 EP disclosed
US-20250387362-A1 COMPOSITIONS FOR AND METHODS OF PRECISION CANCER TREATMENT BURZYNSKI STANISLAW R (US) 2025-12-25 US disclosed
US-20250213515-A1 METHODS FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME BURZYNSKI STANISLAW R (US) 2025-07-03 US disclosed
EP-4568663-A1 COMPOSITIONS FOR AND METHODS OF PRECISION CANCER TREATMENT Burzynski, Stanislaw R. (US) 2025-06-18 EP disclosed
EP-0197358-A2 Topical use of 3-phenylacetylamino-2,6-piperidinedione for treatment of skin wrinkles and hyperpigmentation BURZYNSKI, Stanislaw R. (US) 1986-10-15 EP disclosed
EP-0197358-A2 Topical use of 3-phenylacetylamino-2,6-piperidinedione for treatment of skin wrinkles and hyperpigmentation BURZYNSKI, Stanislaw R. (US) 1986-10-15 EP disclosed
US-4593038-A Applying to skin BURZYNSKI STANISLAW R 1986-06-03 US disclosed
US-4593038-A Applying to skin BURZYNSKI STANISLAW R 1986-06-03 US disclosed
US-4593038-A Applying to skin BURZYNSKI STANISLAW R 1986-06-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250213515-A1 METHODS FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME IDH3B, IDH1, IDH2 GAA 87/4885NPC1 3063/4885RAB9A 2057/4885
US-20250387362-A1 COMPOSITIONS FOR AND METHODS OF PRECISION CANCER TREATMENT SLC25A1, GOT2, FOLH1 GAA 382/4885NPC1 877/4885RAB9A 2844/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.