Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 3/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.33 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596995 | 0.79 | HTR1A (0.39) | AQP1HTR2AHTR2C | |
| SCHEMBL4234706 | 0.79 | AQP1 (0.51) | AQP1SIRT2EZH2HTR2AHTR2C | |
| SCHEMBL4596991 | 0.78 | HTR2A (0.37) | AQP1SIRT2EZH2HTR2AHTR2C | |
| SCHEMBL4793916 | 0.77 | AQP1 (0.46) | AQP1SIRT2EZH2HTR2AHTR2C | |
| SCHEMBL4230246 | 0.77 | AQP1 (0.41) | AQP1SIRT2EZH2HTR2AHTR2C | |
| SCHEMBL4230242 | 0.77 | AQP1 (0.58) | AQP1SIRT2EZH2HTR2AHTR2C | |
| SCHEMBL4836377 | 0.76 | AQP1 (0.36) | AQP1 | |
| SCHEMBL4970746 | 0.74 | AQP1 (0.46) | AQP1EZH2 | |
| SCHEMBL4967601 | 0.74 | AQP1 (0.47) | AQP1 | |
| SCHEMBL4823949 | 0.73 | AQP1 (0.31) | AQP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871355-A1 | NEW THERAPEUTIC COMBIANATIONS FOR THE TREATMENT OR PREVENTION OF DEPRESSION | Wyeth (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116149-A1 | NEW THERAPEUTIC COMBIANATIONS FOR THE TREATMENT OR PREVENTION OF DEPRESSION | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |