Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.33 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4836377 | 0.91 | AQP1 (0.36) | AQP1ALDH1A1MAPK1USP2KDM4E | |
| SCHEMBL4823949 | 0.86 | AQP1 (0.31) | AQP1 | |
| SCHEMBL4623489 | 0.79 | AQP1 (0.49) | AQP1NPC1ALDH1A1HPGDMAPK1 | |
| SCHEMBL4830774 | 0.78 | AQP1 (0.50) | AQP1MAPK1 | |
| SCHEMBL4623485 | 0.78 | AQP1 (0.48) | AQP1NPC1ALDH1A1HPGDCRHR1 | |
| SCHEMBL4224721 | 0.77 | AQP1 (0.74) | AQP1CRHR1F2RL3HSD11B1EZH2 | |
| SCHEMBL4790525 | 0.76 | AQP1 (0.56) | AQP1ALOX15NPC1ALDH1A1HPGD | |
| SCHEMBL5605411 | 0.76 | AQP1 (0.46) | AQP1NPC1ALDH1A1HPGDMAPK1 | |
| SCHEMBL4225189 | 0.75 | AQP1 (0.77) | AQP1ALOX15NPC1ALDH1A1HPGD | |
| SCHEMBL5148555 | 0.75 | DRD2 (0.37) | ALDH1A1MAPK1F2RL3HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879569-A2 | THERAPEUTIC COMBINATIONS FOR THE TREATMENT OR PREVENTION OF PSYCHOTIC DISORDERS | Wyeth (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006116221-A2 | THERAPEUTIC COMBINATIONS FOR THE TREATMENT OR PREVENTION OF PSYCHOTIC DISORDERS | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |