Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 2/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5148555 | 0.87 | DRD2 (0.37) | MAPTTDP1 | |
| SCHEMBL4836377 | 0.86 | AQP1 (0.36) | AQP1MAPTTDP1 | |
| SCHEMBL4970746 | 0.86 | AQP1 (0.46) | AQP1 | |
| SCHEMBL4597074 | 0.78 | BRD4 (0.39) | AQP1CNR1CNR2PTGS1PTGS2 | |
| SCHEMBL4597070 | 0.77 | PTGS1 (0.33) | AQP1CNR1CNR2PTGS1PTGS2 | |
| SCHEMBL4225800 | 0.76 | AQP1 (0.53) | AQP1PTGS1PTGS2MAPT | |
| SCHEMBL4234651 | 0.74 | AQP1 (0.43) | AQP1PTGS1PTGS2 | |
| SCHEMBL4234649 | 0.74 | AQP1 (0.57) | AQP1PTGS1PTGS2KMT2A | |
| SCHEMBL4968328 | 0.74 | GABRP (0.34) | AQP1PTGS2 | |
| SCHEMBL4830774 | 0.73 | AQP1 (0.50) | AQP1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871355-A1 | NEW THERAPEUTIC COMBIANATIONS FOR THE TREATMENT OR PREVENTION OF DEPRESSION | Wyeth (US) | 2008-01-02 | — | — | EP | claimed |
| WO-2006116149-A1 | NEW THERAPEUTIC COMBIANATIONS FOR THE TREATMENT OR PREVENTION OF DEPRESSION | WYETH (US) | 2006-11-02 | — | — | WO | claimed |