Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 2/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4970746 | 0.91 | AQP1 (0.46) | AQP1MAPK1KDM4EALDH1A1USP2 | |
| SCHEMBL4830774 | 0.87 | AQP1 (0.50) | AQP1MAPK1NPSR1MAPTTDP1 | |
| SCHEMBL4823949 | 0.86 | AQP1 (0.31) | AQP1MAPTTDP1 | |
| SCHEMBL4766477 | 0.79 | AQP1 (0.39) | AQP1S1PR4MAPK1KDM4EALDH1A1 | |
| SCHEMBL4766472 | 0.78 | AQP1 (0.38) | AQP1S1PR4MAPK1KDM4EALDH1A1 | |
| SCHEMBL5140412 | 0.78 | AQP1 (0.37) | AQP1S1PR4 | |
| SCHEMBL4220746 | 0.77 | AQP1 (0.60) | AQP1S1PR4KDM4EALDH1A1MAPT | |
| SCHEMBL4789302 | 0.76 | AQP1 (0.45) | AQP1S1PR4 | |
| SCHEMBL4831484 | 0.76 | AQP1 (0.34) | AQP1 | |
| SCHEMBL5606024 | 0.76 | AQP1 (0.37) | AQP1S1PR4MAPK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871355-A1 | NEW THERAPEUTIC COMBIANATIONS FOR THE TREATMENT OR PREVENTION OF DEPRESSION | Wyeth (US) | 2008-01-02 | — | — | EP | claimed |
| WO-2006116149-A1 | NEW THERAPEUTIC COMBIANATIONS FOR THE TREATMENT OR PREVENTION OF DEPRESSION | WYETH (US) | 2006-11-02 | — | — | WO | claimed |
| EP-1871354-A1 | TREATMENT OF PAIN | Wyeth (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116171-A1 | TREATMENT OF PAIN | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |