Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6563535 | 0.97 | POLB (0.33) | POLBIKBKBLIMK1KDM4EGMNN | |
| SCHEMBL9563941 | 0.94 | POLB (0.35) | POLBKDM4EGMNNUSP2ALDH1A1 | |
| SCHEMBL3664084 | 0.91 | LMNA (0.32) | POLBLMNA | |
| SCHEMBL13041036 | 0.89 | POLB (0.33) | POLBKDM4EALDH1A1LMNATP53 | |
| SCHEMBL3660895 | 0.89 | — | — | |
| Methyl Alcohol SCHEMBL20552308 | 0.87 | LMNA (0.33) | POLBKDM4ELMNA | |
| SCHEMBL6391691 | 0.87 | LMNA (0.40) | LMNA | |
| SCHEMBL14958982 | 0.83 | ALDH1A1 (0.37) | POLBKDM4EALDH1A1LMNAGLA | |
| SCHEMBL8147240 | 0.82 | POLB (0.41) | POLBKDM4EGMNNUSP2ALDH1A1 | |
| SCHEMBL9180929 | 0.82 | LMNA (0.35) | LMNACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0484328-B1 | PROCESS FOR THE PREPARATION OF 2,4,6-TRIIODO-5-AMINO-ISOPHTHALAMIDE COMPOUNDS | MALLINCKRODT INC (US) | 1995-06-14 | — | — | EP | claimed |
| US-5191119-A | Process for producing non-ionic radiographic contrast media utilizing N-allylation | COOK IMAGING CORP. (US) | 1993-03-02 | — | — | US | claimed |
| EP-0484328-A1 | PROCESS FOR THE PREPARATION OF 2,4,6-TRIIODO-5-AMINO-N-ALKYLISOPHTHALAMIC ACID AND 2,4,6-TRIIODO-5-AMINO-ISOPHTHALAMIDE COMPOUNDS. | MALLINCKRODT INC (US) | 1992-05-13 | — | — | EP | claimed |
| US-5013865-A | X-ray contrast media, controlled stoichiometry and kinetics | MALLINCKRODT, INC. (US) | 1991-05-07 | — | — | US | claimed |
| WO-1991001296-A1 | PROCESS FOR THE PREPARATION OF 2,4,6-TRIIODO-5-AMINO-N-ALKYLISOPHTHALAMIC ACID AND 2,4,6-TRIIODO-5-AMINO-ISOPHTHALAMIDE COMPOUNDS | MALLINCKRODT, INC. (US) | 1991-02-07 | — | — | WO | claimed |
| EP-2975021-B1 | PROCESS FOR THE PREPARATION OF IOPAMIDOL | BRACCO IMAGING SPA (IT) | 2017-07-26 | — | — | EP | disclosed |
| EP-1353899-B1 | A PROCESS FOR THE PREPARATION OF IOPAMIDOL | BRACCO IMAGING SPA (IT) | 2016-01-20 | — | — | EP | disclosed |
| EP-2975021-A1 | PROCESS FOR THE PREPARATION OF IOPAMIDOL | Bracco Imaging SPA (IT) | 2016-01-20 | — | — | EP | disclosed |
| US-7368101-B2 | Process for the preparation of iopamidol and the new intermediates therein | BRACCO IMAGING S.P.A. (IT) | 2008-05-06 | — | — | US | disclosed |
| EP-0983227-B1 | PREPARATION OF TRI-IODO BENZENE COMPOUNDS | AMERSHAM HEALTH AS (NO) | 2006-08-30 | — | — | EP | disclosed |
| US-20060106253-A1 | Process for the preparation of iopamidol and the new intermediates therein | BRACCO IMAGING S.P.A. (IT) | 2006-05-18 | — | — | US | disclosed |
| US-7034183-B2 | Process for the preparation of iopamidol and the new intermediated therein | BRACCO IMAGING S.P.A. (IT) | 2006-04-25 | — | — | US | disclosed |
| US-5013865-A | X-ray contrast media, controlled stoichiometry and kinetics | MALLINCKRODT, INC. (US) | 1991-05-07 | — | — | US | disclosed |
| WO-1991001296-A1 | PROCESS FOR THE PREPARATION OF 2,4,6-TRIIODO-5-AMINO-N-ALKYLISOPHTHALAMIC ACID AND 2,4,6-TRIIODO-5-AMINO-ISOPHTHALAMIDE COMPOUNDS | MALLINCKRODT, INC. (US) | 1991-02-07 | — | — | WO | disclosed |
| WO-1991001296-A1 | PROCESS FOR THE PREPARATION OF 2,4,6-TRIIODO-5-AMINO-N-ALKYLISOPHTHALAMIC ACID AND 2,4,6-TRIIODO-5-AMINO-ISOPHTHALAMIDE COMPOUNDS | MALLINCKRODT, INC. (US) | 1991-02-07 | — | — | WO | disclosed |
| EP-0406992-A2 | New non-ionic carboxamide contrast agent | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-01-09 | — | — | EP | disclosed |
| EP-0160036-A4 | NOVEL SYNTHETIC METHODS FOR NON-IONIC RADIOGRAPHIC CONTRAST MEDIA. | BIOPHYSICA FOUNDATION (US) | 1987-06-11 | — | — | EP | disclosed |
| EP-0177414-A1 | Jodized triaminobenzene compounds, process for their preparation and their use in contrast products | GUERBET S.A. (FR) | 1986-04-09 | — | — | EP | disclosed |
| EP-0160036-A1 | NOVEL SYNTHETIC METHODS FOR NON-IONIC RADIOGRAPHIC CONTRAST MEDIA | BIOPHYSICA FOUNDATION (US) | 1985-11-06 | — | — | EP | disclosed |
| WO-1985001727-A1 | NOVEL SYNTHETIC METHODS FOR NON-IONIC RADIOGRAPHIC CONTRAST MEDIA | BIOPHYSICA FOUNDATION (US) | 1985-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106253-A1 | Process for the preparation of iopamidol and the new intermediates therein | C9, CBR3, INSR | POLB 3066/4885IKBKB 900/4885LIMK1 4749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.