SCHEMBL3664084

SCHEMBL3664084

NC(=O)c1c(I)c(N)c(I)c(C(=O)O)c1I

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.32
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27558458 0.98 LMNA (0.31) LMNA
Methyl Alcohol SCHEMBL20552308 0.96 LMNA (0.33) LMNAPOLB
SCHEMBL377437 0.91 TPMT (0.33) LMNA
SCHEMBL4833943 0.91 POLB (0.35) LMNAPOLB
SCHEMBL9787543 0.91 LMNA (0.35) LMNAPOLB
SCHEMBL9787544 0.91 LMNA (0.35) LMNAPOLB
Hydrochloric Acid SCHEMBL28391599 0.88 KDM4E (0.32) LMNA
SCHEMBL6397169 0.88 KDM4E (0.32) LMNA
Hydrochloric Acid SCHEMBL620189 0.88 KDM4E (0.32) LMNA
Hydrochloric Acid SCHEMBL9787533 0.88 LMNA (0.34) LMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8445725-B2 Process for the preparation of iosimenol MALLINCKRODT LLC (US) 2013-05-21 US claimed
EP-2240432-B1 PROCESS FOR THE PREPARATION OF IOSIMENOL MALLINCKRODT LLC (US) 2012-07-04 EP claimed
US-20100280270-A1 Process for the Prepartion of Iosimenol MNK 2011 LLC (F/K/A MALLINCKRODT INC.) 2010-11-04 US claimed
EP-2240432-A1 PROCESS FOR THE PREPARATION OF IOSIMENOL Mallinckrodt Inc. (US) 2010-10-20 EP claimed
WO-2009091758-A1 PROCESS FOR THE PREPARATION OF IOSIMENOL MALLINCKRODT INC. (US) 2009-07-23 WO claimed
US-5623044-A URETHANE PREPOLYMER AND REACTION PRODUCT OF SECONDARY AMINOALKOXYSILANE AND POLYISOCYANATE; FOR BONDING GLASS TO METALS ESSEX SPECIALTY PRODUCTS, INC. (US) 1997-04-22 US claimed
US-20220048852-A1 PROCESS OF PREPARING IOSIMENOL OTSUKA PHARMA CO LTD (JP) 2022-02-17 US disclosed
US-20220048852-A1 PROCESS OF PREPARING IOSIMENOL OTSUKA PHARMA CO LTD (JP) 2022-02-17 US disclosed
US-20220048852-A1 PROCESS OF PREPARING IOSIMENOL OTSUKA PHARMA CO LTD (JP) 2022-02-17 US disclosed
US-20200095191-A1 PROCESS OF PREPARING IOSIMENOL OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2020-03-26 US disclosed
US-20200095191-A1 PROCESS OF PREPARING IOSIMENOL OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2020-03-26 US disclosed
EP-3619192-A1 PROCESS OF PREPARING IOSIMENOL Otsuka Pharmaceutical Co., Ltd. (JP) 2020-03-11 EP disclosed
EP-3619192-A1 PROCESS OF PREPARING IOSIMENOL Otsuka Pharmaceutical Co., Ltd. (JP) 2020-03-11 EP disclosed
US-5851261-A Process for the production of polyurea encapsulated fertilizer particles and the encapsulated fertilizer particles produced by this process BAYER CORPORATION (US) 1998-12-22 US disclosed
US-5698739-A RADIOLOGY SCHERING AKTIENGESELLSCHAFT (DE) 1997-12-16 US disclosed
US-5210246-A Reacting a tetraalkoxysilicate with aminoalcohol MITSUBISHI KASEI CORPORATION (JP) 1993-05-11 US disclosed
US-5102924-A Toughness MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1992-04-07 US disclosed
US-4988549-A CURABLE POLYISOCYANATE, POLYEPOXIDE REACTION MIXTURE ON POLYAMIDE BAYER AKTIENGESELLSCHAFT (DE) 1991-01-29 US disclosed
US-4943603-A POLYURETHANES, POLYUREAS FILLED WITH WOLLASTONITE THE DOW CHEMICAL COMPANY (US) 1990-07-24 US disclosed
US-4264572-A TRIIODOISOPHTHALMIC ACID COMPOUNDS FOR MEDICAL DIAGNOSIS SCHERING AKTIENGESELLSCHAFT (DE) 1981-04-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200095191-A1 PROCESS OF PREPARING IOSIMENOL AOC2, SSTR5, SSTR2 LMNA 2553/4885POLB 1216/4885
US-20100280270-A1 Process for the Prepartion of Iosimenol DHCR24, DRD4, NONO LMNA 713/4885POLB 808/4885
US-20220048852-A1 PROCESS OF PREPARING IOSIMENOL AOC2, SSTR2, NISCH LMNA 3153/4885POLB 1889/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.