Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.47 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | EDNRA | P25101 | 2/20 | 0.41 |
| ▸ | EDNRB | P24530 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4777634 | 0.88 | SLC40A1 (0.47) | HPGDSLC40A1GLO1EDNRAEDNRB | |
| SCHEMBL4777374 | 0.87 | GLO1 (0.43) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4781821 | 0.85 | SLC40A1 (0.49) | LMNAMEN1KMT2ASLC40A1GLO1 | |
| SCHEMBL4781338 | 0.81 | SLC40A1 (0.48) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4727568 | 0.80 | GFER (0.43) | ALDH1A1LMNAMEN1KMT2AHPGD | |
| SCHEMBL8660294 | 0.76 | MCL1 (0.53) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4727559 | 0.74 | SLC40A1 (0.51) | LMNAMEN1KMT2ASLC40A1GAA | |
| SCHEMBL30304828 | 0.74 | SLC40A1 (0.51) | LMNAMEN1KMT2ASLC40A1GAA | |
| SCHEMBL4775751 | 0.71 | SLC40A1 (0.44) | HPGDSLC40A1GLO1MAPTEDNRA | |
| SCHEMBL8660042 | 0.71 | HPGD (0.53) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |