Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.44 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.43 |
| ▸ | EDNRB | P24530 | 2/20 | 0.42 |
| ▸ | EDNRA | P25101 | 2/20 | 0.42 |
| ▸ | PGR | P06401 | 4/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | CCR4 | P51679 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781224 | 0.86 | GFER (0.43) | GLO1CYP2C9CYP2C19HPGDMAPT | |
| SCHEMBL4780514 | 0.85 | GLO1 (0.41) | GLO1PGRCYP2C9CYP2C19FBP1 | |
| SCHEMBL3089179 | 0.84 | SLC40A1 (0.46) | SLC40A1EDNRBEDNRAPGRACLY | |
| SCHEMBL4777634 | 0.83 | SLC40A1 (0.47) | SLC40A1GLO1EDNRBEDNRAPGR | |
| SCHEMBL4842459 | 0.81 | ALDH1A1 (0.47) | SLC40A1EDNRBEDNRAPGRKDM1A | |
| SCHEMBL3095682 | 0.78 | PIK3C2B (0.36) | PGRKDM1AMAOAACLYHPGD | |
| SCHEMBL8662810 | 0.76 | HPGD (0.51) | PGRKDM1AMAOAACLYHPGD | |
| SCHEMBL4840971 | 0.71 | ALDH1A1 (0.47) | SLC40A1GLO1EDNRBEDNRACYP2C9 | |
| SCHEMBL8658312 | 0.71 | HPGD (0.53) | CYP2C9CYP2C19HPGDMAPT | |
| SCHEMBL8660153 | 0.71 | HPGD (0.53) | SLC40A1ACLYHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | claimed |
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |