Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.50 |
| ▸ | FDPS | P14324 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | NSD2 | O96028 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15939820 | 0.86 | NPC1 (0.60) | HPGDALDH1A1KDM4ECYP2D6CYP2C19 | |
| SCHEMBL29935885 | 0.85 | CYP1A2 (0.55) | HPGDALDH1A1KDM4ECYP2D6CYP2C19 | |
| SCHEMBL9156343 | 0.85 | CYP1A2 (0.55) | HPGDALDH1A1KDM4ECYP2D6CYP2C19 | |
| SCHEMBL10604929 | 0.85 | HPGD (0.67) | HPGDALDH1A1KDM4ECYP2D6RCE1 | |
| SCHEMBL28029765 | 0.84 | HPGD (0.54) | HPGDALDH1A1KDM4ECYP2D6CYP2C19 | |
| SCHEMBL5929981 | 0.83 | HPGD (0.50) | HPGDALDH1A1KDM4ECYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL11157053 | 0.83 | CYP1A2 (0.53) | HPGDALDH1A1KDM4ECYP2D6CYP2C19 | |
| SCHEMBL10416108 | 0.82 | HPGD (0.57) | HPGDALDH1A1KDM4ECYP2D6CYP2C19 | |
| SCHEMBL4598193 | 0.81 | MTNR1A (0.46) | HPGDALDH1A1KDM4ECYP2D6CYP2C19 | |
| SCHEMBL29508722 | 0.81 | HPGD (0.79) | HPGDALDH1A1KDM4ECYP2D6RCE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230391730-A1 | INHIBITORS OF THE BROMODOMAIN PHD FINGER TRANSCRIPTION FACTOR (BPTF) AS ANTI-CANCER AGENTS | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2023-12-07 | — | — | US | disclosed |
| US-20230137893-A1 | PYRROLO[2,3-b]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | THE ROCKEFELLER UNIVERSITY (US) | 2023-05-04 | — | — | US | disclosed |
| WO-2020255038-A1 | COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND PYRIDOPYRIMIDINE DERIVATIVES | Janssen Sciences Ireland Unlimited Company (IE) | 2020-12-24 | — | — | WO | disclosed |
| US-10590112-B2 | Dihydropyrimidinyl benzazepine carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2020-03-17 | — | — | US | disclosed |
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |
| US-20190135788-A1 | DIHYDROPYRIMIDINYL BENZAZEPINE CARBOXAMIDE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2019-05-09 | — | — | US | disclosed |
| US-10022376-B2 | Pyrazolopyridines and pyrazolopyrimidines | PFIZER INC. (US) | 2018-07-17 | — | — | US | disclosed |
| EP-3143021-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | Pfizer Inc (US) | 2017-03-22 | — | — | EP | disclosed |
| US-20170071946-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER INC. (US) | 2017-03-16 | — | — | US | disclosed |
| US-20160362408-A1 | ARYL- AND HETARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE-3-CARBOXAMIDES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-12-15 | — | — | US | disclosed |
| US-20150329542-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER INC. | 2015-11-19 | — | — | US | disclosed |
| WO-2015173683-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER INC. (US) | 2015-11-19 | — | — | WO | disclosed |
| US-7465811-B2 | Indoline compounds | LABORATOIRES FOURNIER S.A. (FR) | 2008-12-16 | — | — | US | disclosed |
| US-20080119465-A1 | Novel Indoline Compounds | LABORATORIES FOURNIER S.A. (FR) | 2008-05-22 | — | — | US | disclosed |
| US-20060223826-A1 | Indole derivatives as somatostatin agonists or antagonists | TAKEDA PHARMACEUTICAL COMPANY LIMITED INTELLECTUAL PROPERTY DEPARTMENT (JP) | 2006-10-05 | — | — | US | disclosed |
| US-20060173034-A1 | Novel 4-anilinoquinoline-3-carboxamides | ASTRAZENECA AB (SE) | 2006-08-03 | — | — | US | disclosed |
| US-7037925-B2 | 4-anilinoquinoline-3-carboxamides | ASTRAZENECA AB (SE) | 2006-05-02 | — | — | US | disclosed |
| US-20040248923-A1 | Novel 4-anilinoquinoline-3-carboxamides | ASTRAZENECA AB (SE) | 2004-12-09 | — | — | US | disclosed |
| EP-1387830-A1 | NOVEL 4-ANILINOQUINOLINE-3-CARBOXAMIDES | AstraZeneca AB (SE) | 2004-02-11 | — | — | EP | disclosed |
| WO-2002092571-A1 | NOVEL 4-ANILINOQUINOLINE-3-CARBOXAMIDES | ASTRAZENECA AB (SE) | 2002-11-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223826-A1 | Indole derivatives as somatostatin agonists or antagonists | SSTR1, SSTR3, NPY1R | HPGD 2131/4885ALDH1A1 2632/4885KDM4E 2069/4885 |
| US-20160362408-A1 | ARYL- AND HETARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE-3-CARBOXAMIDES AND USE THEREOF | AADAC, PAH, CYP2C8 | HPGD 167/4885ALDH1A1 654/4885KDM4E 2730/4885 |
| US-20080119465-A1 | Novel Indoline Compounds | GPR119, INSR, IRS1 | HPGD 3316/4885ALDH1A1 1819/4885KDM4E 1574/4885 |
| US-20190135788-A1 | DIHYDROPYRIMIDINYL BENZAZEPINE CARBOXAMIDE COMPOUNDS | TLR8, TLR1, TLR5 | HPGD 3296/4885ALDH1A1 1894/4885KDM4E 1129/4885 |
| US-10590112-B2 | Dihydropyrimidinyl benzazepine carboxamide compounds | TLR8, TLR1, TLR5 | HPGD 3296/4885ALDH1A1 1894/4885KDM4E 1129/4885 |
| US-10022376-B2 | Pyrazolopyridines and pyrazolopyrimidines | CBR3, HRH4, REN | HPGD 1740/4885ALDH1A1 2993/4885KDM4E 4113/4885 |
| US-20150329542-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | HRH2, HRH4, HRH1 | HPGD 2891/4885ALDH1A1 3745/4885KDM4E 4660/4885 |
| US-20040248923-A1 | Novel 4-anilinoquinoline-3-carboxamides | JAK3, JAK2, JAK1 | HPGD 3742/4885ALDH1A1 2836/4885KDM4E 488/4885 |
| US-20230391730-A1 | INHIBITORS OF THE BROMODOMAIN PHD FINGER TRANSCRIPTION FACTOR (BPTF) AS ANTI-CANCER AGENTS | BPTF, BRPF3, PHF6 | HPGD 2969/4885ALDH1A1 2997/4885KDM4E 709/4885 |
| US-20230137893-A1 | PYRROLO[2,3-b]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | LATS2, LATS1, YAP1 | HPGD 2492/4885ALDH1A1 3775/4885KDM4E 1083/4885 |
| US-20060173034-A1 | Novel 4-anilinoquinoline-3-carboxamides | JAK3, JAK2, JAK1 | HPGD 4243/4885ALDH1A1 3672/4885KDM4E 455/4885 |
| US-20170071946-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | HRH2, HRH4, HRH1 | HPGD 2891/4885ALDH1A1 3745/4885KDM4E 4660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.