Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.39 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1574085 | 0.85 | ALOX15 (0.54) | KITFLT3DRD2DRD4DRD3 | |
| SCHEMBL16242493 | 0.76 | FAAH (0.42) | LMNAALDH1A1RECQLMAPK1ALOX15 | |
| SCHEMBL1574198 | 0.71 | TP53 (0.47) | MAP2K4MAPK1MAPK6TSHRSMN1; SMN2 | |
| SCHEMBL1573862 | 0.71 | ALDH1A1 (0.44) | MAP2K4LMNAALDH1A1MAPK1MAPK6 | |
| SCHEMBL28039585 | 0.70 | MAP2K4 (0.51) | MAP2K4MAPK1MAPK6HTR2A | |
| SCHEMBL1574118 | 0.70 | FLT3 (0.47) | FLT3MAPK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1574020 | 0.69 | L3MBTL1 (0.47) | ALDH1A1SMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL1573919 | 0.69 | HRH4 (0.47) | KITFLT3MAP2K4ALDH1A1MAPK1 | |
| SCHEMBL1573602 | 0.69 | KDM4E (0.51) | ALDH1A1TSHRSMN1; SMN2HPGDKDM4E | |
| SCHEMBL1573781 | 0.69 | MAP2K4 (0.41) | MAP2K4ALDH1A1MAPK1MAPK6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937648-B1 | DIACYL INDAZOL DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS | SANOFI SA (FR) | 2014-11-26 | — | — | EP | disclosed |
| EP-1937648-A1 | DIACYL INDAZOL DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS | sanofi-aventis (FR) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007042178-A1 | DIACYL INDAZOL DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS | SANOFI-AVENTIS (DE) | 2007-04-19 | — | — | WO | disclosed |