Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 7/20 | 0.44 |
| ▸ | DRD1 known ✓ | P21728 | 4/20 | 0.44 |
| ▸ | ADRA1D known ✓ | P25100 | 4/20 | 0.44 |
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.44 |
| ▸ | HTR2C known ✓ | P28335 | 4/20 | 0.44 |
| ▸ | ADRA1A known ✓ | P35348 | 4/20 | 0.44 |
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.44 |
| ▸ | ADRA1B known ✓ | P35368 | 4/20 | 0.44 |
| ▸ | HTR2B known ✓ | P41595 | 4/20 | 0.44 |
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.44 |
| ▸ | ADRA2B known ✓ | P18089 | 3/20 | 0.44 |
| ▸ | ADRA2C known ✓ | P18825 | 3/20 | 0.44 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.42 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.42 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 10/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4844561 | 1.00 | CHRM1 (0.44) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| Maleic Acid SCHEMBL4847915 | 0.96 | CHRM1 (0.45) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| Fumaric Acid SCHEMBL4847927 | 0.96 | CHRM1 (0.45) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL14156733 | 0.93 | CHRM1 (0.48) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL6207006 | 0.89 | CHRM1 (0.49) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL14156732 | 0.89 | CHRM1 (0.49) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL14156741 | 0.85 | CHRM1 (0.38) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL14156754 | 0.83 | DRD2 (0.42) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL4844246 | 0.83 | DRD2 (0.41) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL4844260 | 0.83 | DRD2 (0.41) | CHRM1DRD2CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384934-B2 | Piperazine substituted aryl benzodiazepines | ELI LILLY AND COMPANY (US) | 2008-06-10 | — | — | US | disclosed |
| EP-1546134-B1 | PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES | LILLY CO ELI (US) | 2007-05-02 | — | — | EP | disclosed |
| US-20060084643-A1 | Piperazine substituted aryl benzodiazepines | ELI LILLY AND COMPANY | 2006-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084643-A1 | Piperazine substituted aryl benzodiazepines | GABBR1, GABBR2, GABRA5 | DRD2 7/4885DRD1 20/4885ADRA1D 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.