Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.40 |
| ▸ | AGTR1 known ✓ | P30556 | 1/20 | 0.35 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL28968004 | 1.00 | LMNA (0.50) | LMNAUSP2ALDH1A1KDM4ETHRB | |
| Glycerin SCHEMBL28968005 | 0.97 | LMNA (0.56) | LMNAUSP2ALDH1A1KDM4ETHRB | |
| Water SCHEMBL27747101 | 0.97 | USP2 (0.48) | LMNAUSP2ALDH1A1KDM4ETHRB | |
| Water SCHEMBL27671478 | 0.97 | USP2 (0.48) | LMNAUSP2ALDH1A1KDM4ETHRB | |
| SCHEMBL30754 | 0.97 | LMNA (0.53) | LMNAUSP2ALDH1A1KDM4ETHRB | |
| SCHEMBL1638881 | 0.97 | LMNA (0.53) | LMNAUSP2ALDH1A1KDM4ETHRB | |
| SCHEMBL25238278 | 0.93 | LMNA (0.50) | LMNAUSP2ALDH1A1KDM4ETHRB | |
| Glycerin SCHEMBL2582537 | 0.93 | LMNA (0.60) | LMNAUSP2ALDH1A1KDM4ETHRB | |
| SCHEMBL15894238 | 0.93 | LMNA (0.50) | LMNAUSP2ALDH1A1KDM4ETHRB | |
| SCHEMBL821029 | 0.93 | LMNA (0.50) | LMNAUSP2ALDH1A1KDM4ETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1196734-C | Foamed polyester resin moulding and process for producing the same | NIPPON RESIN RES INST CO LTD (JP) | 2005-04-13 | — | — | CN | claimed |
| CN-1325420-A | Foamed polyester resin moulding and process for producing the same | NIPPON RESIN RES INST CO LTD (JP) | 2001-12-05 | — | — | CN | claimed |
| WO-2020181642-A1 | PREPARATION METHOD FOR IONIC BOND-COVALENT BOND SYNERGY-BASED SURFACE HEPARINIZED ANTICOAGULANT MEDICAL DEVICE | 江苏赛腾医疗科技有限公司 | 2020-09-17 | — | — | WO | disclosed |
| CN-103360728-A | Phosphorus-containing copolyester foam combined material and method for preparing phosphorus-containing copolyester foam by adopting phosphorus-containing copolyester foam combined material | CHANGZHOU TIANSHENG NEW MATERIALS STOCK CO LTD | 2013-10-23 | — | — | CN | disclosed |
| EP-2002010-A2 | BIOMASS FUEL SYNTHESIS METHODS FOR INCRESED ENERGY EFFICIENCY | ALTERVIA ENERGY, LLC (US) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007112090-A2 | BIOMASS FUEL SYNTHESIS METHODS FOR INCRESED ENERGY EFFICIENCY | ALTERVIA ENERGY, LLC (US) | 2007-10-04 | — | — | WO | disclosed |
| US-20070161095-A1 | Biomass Fuel Synthesis Methods for Increased Energy Efficiency | ALTERVIA ENERGY, LLC | 2007-07-12 | — | — | US | disclosed |
| CN-1325415-C | Dielectric/spacer composite for plasma display and method of manufacturing the same | KOREA ADVANCED INST SCI & TECH (KR) | 2007-07-11 | — | — | CN | disclosed |
| CN-1272361-C | photosensitive resin, resin composition and cured product thereof | NIPPON KAYAKU KK (JP) | 2006-08-30 | — | — | CN | disclosed |
| CN-1680207-A | Dielectric/spacer composite for plasma display and method of manufacturing the same | KOREA INST SCI & TECH (KR) | 2005-10-12 | — | — | CN | disclosed |
| CN-1196734-C | Foamed polyester resin moulding and process for producing the same | NIPPON RESIN RES INST CO LTD (JP) | 2005-04-13 | — | — | CN | disclosed |
| CN-1471551-A | High functional polymers | 万迪科股份公司 | 2004-01-28 | — | — | CN | disclosed |
| CN-1427020-A | Water-soluble resin and its application in paper paint | SUMITOMO CHEMICAL CO (JP) | 2003-07-02 | — | — | CN | disclosed |
| CN-1101413-C | Water-soluble resin and application thereof in paper coating | SUMITOMO CHEMICAL CO (JP) | 2003-02-12 | — | — | CN | disclosed |
| CN-1083871-C | Epoxy Adhesives Containing Dithiooxamide Adhesion Promoters | MINNESOTA MINING & MFG (US) | 2002-05-01 | — | — | CN | disclosed |
| CN-1325420-A | Foamed polyester resin moulding and process for producing the same | NIPPON RESIN RES INST CO LTD (JP) | 2001-12-05 | — | — | CN | disclosed |
| CN-1180369-A | Epoxy adhesives containing dithio * amide adhesion promoters | MINNESOTA MINNG AND MANUFACTUR (US) | 1998-04-29 | — | — | CN | disclosed |
| CN-1168390-A | Water-soluble resin and application thereof in paper coating | SUMITOMO CHEMICAL CO (JP) | 1997-12-24 | — | — | CN | disclosed |
| CN-1026009-C | Process for coating electrically conducting substrates, substrates coated by this process and aqueous electrocoating baths | BASF LACKE & FARBEN (DE) | 1994-09-28 | — | — | CN | disclosed |
| CN-1039074-A | The technology ground that this technology is coated with and the moisture electric coating groove of electropaining electrically conductive substrates | BASF LACKE & FARBEN (DE) | 1990-01-24 | — | — | CN | disclosed |