SCHEMBL4847149

SCHEMBL4847149

C1=NC(c2ccccc2)(c2ccc(-c3ccc(C4(c5ccccc5)N=CC=N4)cc3)cc2)N=C1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.36
AKT2 P31751 1/20 0.34
SLC6A2 P23975 3/20 0.33
SLC6A4 P31645 3/20 0.33
SLC6A3 Q01959 3/20 0.33
MMP3 P08254 2/20 0.33
MAPK1 P28482 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
TAAR1 Q96RJ0 1/20 0.33
HSD17B10 Q99714 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
NOTUM Q6P988 1/20 0.33
BCL2L1 Q07817 1/20 0.33
MEN1 O00255 1/20 0.32
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
KMT2A Q03164 1/20 0.32
MMP2 P08253 1/20 0.32
MMP9 P14780 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4855699 0.73 KDM4E (0.37) ALDH1A1SLC6A2SLC6A4SLC6A3MAPK1
SCHEMBL5274311 0.69 OPRM1 (0.33) TAAR1KMT2A
SCHEMBL10928766 0.68 OPRM1 (0.36) ALDH1A1TAAR1MEN1KMT2A
Bromide SCHEMBL29801969 0.67 OPRM1 (0.32) TAAR1KMT2A
SCHEMBL9013702 0.65 LMNA (0.38) ALDH1A1MEN1KMT2AMMP2MMP9
SCHEMBL1067618 0.65 OPRL1 (0.33) ALDH1A1TDP1MEN1NPC1RAB9A
SCHEMBL143471 0.62 ALDH1A1 (0.90) ALDH1A1SLC6A4MMP3MAPK1CYP1A2
SCHEMBL2637802 0.62 ALDH1A1 (0.90) ALDH1A1SLC6A4MMP3MAPK1CYP1A2
Tannin Pyrogallol SCHEMBL21448 0.62 ALDH1A1 (0.90) ALDH1A1SLC6A4MMP3MAPK1CYP1A2
SCHEMBL1991754 0.62 ALDH1A1 (0.90) ALDH1A1SLC6A4MMP3MAPK1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7388100-B2 Tertiary amine compounds NISHIO TETSUYA 2008-06-17 US disclosed
US-20060145145-A1 Tertiary amine compounds, organic semiconductor devices using the same and organic electroluminescence devices using the same NISHIO TETSUYA 2006-07-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060145145-A1 Tertiary amine compounds, organic semiconductor devices using the same and organic electroluminescence devices using the same PIEZO1, YES1, SAT1 ALDH1A1 592/4885AKT2 4083/4885SLC6A2 258/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.