Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LIPE | Q05469 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | GCGR | P47871 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7097264 | 0.85 | ALDH1A1 (0.45) | HTR2AHTR2CALDH1A1L3MBTL1MAPT | |
| SCHEMBL2959406 | 0.79 | NPC1 (0.56) | HTR2AHTR2CALDH1A1L3MBTL1ABL1 | |
| SCHEMBL2952936 | 0.78 | ALDH1A1 (0.52) | HTR2AHTR2CALDH1A1L3MBTL1LIPE | |
| SCHEMBL2956291 | 0.76 | HTR2A (0.67) | HTR2AHTR2CALDH1A1L3MBTL1ABL1 | |
| SCHEMBL4850458 | 0.75 | ALDH1A1 (0.41) | HTR2AHTR2CALDH1A1L3MBTL1MAPT | |
| SCHEMBL6601831 | 0.74 | HTR2A (0.39) | HTR2AHTR2CALDH1A1L3MBTL1ABL1 | |
| SCHEMBL2954162 | 0.73 | ALDH1A1 (0.59) | HTR2AALDH1A1L3MBTL1MAPT | |
| SCHEMBL7153301 | 0.72 | HTR2A (0.54) | HTR2AALDH1A1L3MBTL1RAB9A | |
| SCHEMBL8169266 | 0.67 | PTGDR2 (0.46) | HTR2AALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL3102713 | 0.66 | L3MBTL1 (0.52) | ALDH1A1L3MBTL1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368539-B2 | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-06 | — | — | US | disclosed |
| US-20050119182-A1 | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | ARENA PHARMACEUTICALS, INC. (US) | 2005-06-02 | — | — | US | disclosed |
| US-20030224442-A1 | Non-endogeneous, constitutively activated human serotonin receptors and small molecule modualtors thereof | BEHAN DOMINIC P (US) | 2003-12-04 | — | — | US | disclosed |
| US-6140509-A | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | ARENA PHARMACEUTICALS, INC. (US) | 2000-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119182-A1 | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | HTR2A, HTR3B, HTR3A | HTR2A 1/4885HTR2C 4/4885ALDH1A1 3499/4885 |
| US-20030224442-A1 | Non-endogeneous, constitutively activated human serotonin receptors and small molecule modualtors thereof | HTR2A, HTR5A, HTR1A | HTR2A 1/4885HTR2C 6/4885ALDH1A1 3419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.