Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4850458 | 0.89 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2L3MBTL1PLA2G1BATG4B | |
| SCHEMBL4852479 | 0.85 | HTR2A (0.44) | ALDH1A1L3MBTL1MAPTKMT2AHTR2C | |
| SCHEMBL6587577 | 0.80 | GPBAR1 (0.39) | MAPTHTTKMT2ANPSR1GPBAR1 | |
| SCHEMBL2959175 | 0.76 | L3MBTL1 (0.61) | ALDH1A1SMN1; SMN2L3MBTL1LMNAMAPT | |
| SCHEMBL2958803 | 0.72 | HTR2A (0.64) | ALDH1A1L3MBTL1MAPTHTR2A | |
| SCHEMBL3102713 | 0.71 | L3MBTL1 (0.52) | ALDH1A1L3MBTL1ALPL | |
| SCHEMBL9767710 | 0.69 | CES2 (0.53) | ALDH1A1SMN1; SMN2L3MBTL1LMNAPOLB | |
| SCHEMBL9933095 | 0.69 | SMN1; SMN2 (0.49) | ALDH1A1SMN1; SMN2L3MBTL1POLBMAPT | |
| SCHEMBL31352766 | 0.69 | L3MBTL1 (0.51) | ALDH1A1SMN1; SMN2L3MBTL1LMNAMAPT | |
| SCHEMBL26112325 | 0.69 | L3MBTL1 (0.51) | ALDH1A1SMN1; SMN2L3MBTL1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030224442-A1 | Non-endogeneous, constitutively activated human serotonin receptors and small molecule modualtors thereof | BEHAN DOMINIC P (US) | 2003-12-04 | — | — | US | disclosed |
| US-6140509-A | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | ARENA PHARMACEUTICALS, INC. (US) | 2000-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030224442-A1 | Non-endogeneous, constitutively activated human serotonin receptors and small molecule modualtors thereof | HTR2A, HTR5A, HTR1A | ALDH1A1 3419/4885SMN1; SMN2 4747/4885L3MBTL1 2801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.