Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | NOS1 | P29475 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | NOS2 | P35228 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | NOS3 | P29474 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL922796 | 0.77 | ALDH1A1 (0.62) | ALDH1A1TDP1NOS1SMN1; SMN2MEN1 | |
| SCHEMBL29674805 | 0.72 | ALDH1A1 (0.61) | ALDH1A1TDP1NOS1SMN1; SMN2MEN1 | |
| SCHEMBL643317 | 0.72 | ALDH1A1 (0.61) | ALDH1A1TDP1NOS1SMN1; SMN2MEN1 | |
| SCHEMBL1010663 | 0.72 | ALDH1A1 (0.61) | ALDH1A1TDP1NOS1SMN1; SMN2MEN1 | |
| SCHEMBL5143485 | 0.72 | ALDH1A1 (0.51) | ALDH1A1TDP1NOS1MEN1KMT2A | |
| Methane SCHEMBL27506999 | 0.71 | ALDH1A1 (0.59) | ALDH1A1TDP1NOS1SMN1; SMN2MEN1 | |
| SCHEMBL27415737 | 0.71 | ALDH1A1 (0.59) | ALDH1A1TDP1NOS1SMN1; SMN2MEN1 | |
| Bromide SCHEMBL11820178 | 0.71 | ALDH1A1 (0.59) | ALDH1A1TDP1NOS1SMN1; SMN2MEN1 | |
| SCHEMBL3292426 | 0.70 | ALDH1A1 (0.63) | ALDH1A1TDP1NOS1SMN1; SMN2MEN1 | |
| SCHEMBL9735773 | 0.70 | ALDH1A1 (0.69) | ALDH1A1TDP1NOS1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335678-B2 | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1(VR1) receptor | ABBOTT LABORATORIES (US) | 2008-02-26 | — | — | US | disclosed |
| US-20040209884-A1 | Fused azabicycic compounds that inhibit vanilloid receptor subtype 1(VR1) receptor | ABBVIE INC. | 2004-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040209884-A1 | Fused azabicycic compounds that inhibit vanilloid receptor subtype 1(VR1) receptor | TRPV1, TMEM109, GPR55 | ALDH1A1 350/4885TDP1 2701/4885NOS1 772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.