SCHEMBL4855268

SCHEMBL4855268

CCOC(=O)C(Cc1ccc(OCc2ccccc2)cc1)C(C)=O

nearest known ligand 0.62

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.62
L3MBTL1 Q9Y468 1/20 0.62
PPARA Q07869 4/20 0.57
PPARG P37231 4/20 0.57
PPARD Q03181 1/20 0.57
MMP8 P22894 1/20 0.56
ALOX5 P09917 4/20 0.55
LTA4H P09960 2/20 0.54
MAOB P27338 2/20 0.54
NR1H4 Q96RI1 1/20 0.53
ALDH1A1 P00352 1/20 0.53
LAP3 P28838 1/20 0.53
FFAR1 O14842 1/20 0.52
FFAR4 Q5NUL3 1/20 0.52
PTGS1 P23219 1/20 0.51
PTGS2 P35354 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9493387 0.93 L3MBTL1 (0.67) LMNAL3MBTL1PPARAPPARGPPARD
SCHEMBL27385612 0.92 LMNA (0.65) LMNAL3MBTL1PPARAPPARGPPARD
SCHEMBL15707904 0.90 LMNA (0.62) LMNAL3MBTL1PPARAPPARGPPARD
SCHEMBL6691879 0.89 MAOB (0.62) LMNAL3MBTL1PPARAPPARGPPARD
SCHEMBL6312211 0.88 LTA4H (0.65) PPARAPPARGPPARDALOX5LTA4H
SCHEMBL856250 0.87 MMP8 (0.69) LMNAL3MBTL1PPARGMMP8ALDH1A1
SCHEMBL27539789 0.86 L3MBTL1 (0.61) LMNAL3MBTL1PPARAPPARGPPARD
SCHEMBL6713179 0.85 LMNA (0.64) LMNAL3MBTL1PPARAPPARGPPARD
SCHEMBL7501342 0.85 LMNA (0.64) LMNAL3MBTL1PPARAPPARGPPARD
SCHEMBL27461095 0.85 LMNA (0.57) LMNAL3MBTL1PPARAPPARGPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9434670-B2 Family of aryl, heteroaryl, O-aryl and O-heteroaryl carbasugars TFCHEM (FR) 2016-09-06 US disclosed
US-20140105839-A1 FAMILY OF ARYL, HETEROARYL, O-ARYL AND O-HETEROARYL CARBASUGARS TF-CHEM (FR) 2014-04-17 US disclosed
EP-1660509-B1 GLUCOPYRANOSYLOXY- PYRAZOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THE USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF BOEHRINGER INGELHEIM INT (DE) 2009-02-04 EP disclosed
US-7375090-B2 Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-05-20 US disclosed
US-7375090-B2 Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-05-20 US disclosed
US-7375090-B2 Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-05-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140105839-A1 FAMILY OF ARYL, HETEROARYL, O-ARYL AND O-HETEROARYL CARBASUGARS SLC5A2, SLC5A1, SLC2A2 LMNA 3870/4885L3MBTL1 1473/4885PPARA 1712/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.