Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4849790 | 0.83 | MEN1 (0.53) | SLC6A2SLC6A4SLC6A3GAAMAPT | |
| SCHEMBL11313806 | 0.82 | MAPT (0.59) | SLC6A2SLC6A4KDM4CSLC6A3PTGES2 | |
| SCHEMBL4847902 | 0.82 | PKM (0.51) | SLC6A2SLC6A4KDM4CSLC6A3MAPK1 | |
| SCHEMBL9265704 | 0.76 | LTA4H (0.51) | CYP17A1GAAMAPTTSHRHTT | |
| SCHEMBL8151401 | 0.73 | TRPV4 (0.52) | SLC6A2SLC6A4KDM4CSLC6A3PTGES2 | |
| SCHEMBL2152147 | 0.73 | TTR (0.47) | SLC6A2SLC6A4KDM4CSLC6A3PTGES2 | |
| SCHEMBL4857891 | 0.73 | ALDH1A1 (0.43) | SLC6A2SLC6A4KDM4CSLC6A3PTGES2 | |
| SCHEMBL7666763 | 0.72 | TRPV4 (0.50) | SLC6A2SLC6A4KDM4CSLC6A3PTGES2 | |
| SCHEMBL4422704 | 0.72 | TRPV4 (0.46) | SLC6A2SLC6A4KDM4CSLC6A3PTGES2 | |
| SCHEMBL1679612 | 0.72 | PDCD1 (0.50) | PDE4BPDE4DSLC6A2SLC6A4KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456169-B2 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | MAP3K20, MAP3K19, MAP4K2 | PDE4B 890/4885PDE4D 1290/4885SLC6A2 4748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.