Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.48 |
| ▸ | NPC1 | O15118 | 8/20 | 0.48 |
| ▸ | RAB9A | P51151 | 8/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PBK | Q96KB5 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL486100 | 0.88 | RAB9A (0.44) | KDM4ENPC1RAB9APKMLMNA | |
| SCHEMBL485752 | 0.88 | KDM4E (0.46) | KDM4ENPC1RAB9APKMLMNA | |
| Formic Acid SCHEMBL27713038 | 0.85 | PIN1 (0.42) | KDM4ENPC1RAB9APKMLMNA | |
| SCHEMBL485467 | 0.82 | CXCR2 (0.55) | KDM4ENPC1RAB9APKMLMNA | |
| SCHEMBL485291 | 0.77 | CXCR2 (0.44) | KDM4ENPC1RAB9APKMLMNA | |
| Formic Acid SCHEMBL27693208 | 0.76 | ALOX5AP (0.51) | KDM4ERAB9ALMNAALDH1A1KMT2A | |
| SCHEMBL486027 | 0.76 | MAOB (0.50) | KDM4ENPC1RAB9ALMNAALDH1A1 | |
| Formic Acid SCHEMBL27713042 | 0.74 | SCN9A (0.43) | KDM4ERAB9ALMNAALDH1A1MEN1 | |
| SCHEMBL485598 | 0.74 | MAOB (0.53) | KDM4ENPC1RAB9ALMNAALDH1A1 | |
| Formic Acid SCHEMBL27693263 | 0.74 | MEN1 (0.57) | KDM4ENPC1RAB9AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836158-B1 | FUSED BICYCLIC CARBOXAMIDE DERIVATIVES FOR USE AS CXCR2 INHIBITORS IN THE TREATMENT OF INFLAMMATION | SANOFI AVENTIS DEUTSCHLAND (DE) | 2012-02-01 | — | — | EP | claimed |