Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.46 |
| ▸ | NPC1 | O15118 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485671 | 0.88 | KDM4E (0.48) | KDM4ENPC1RAB9APKMLMNA | |
| Formic Acid SCHEMBL27713042 | 0.86 | SCN9A (0.43) | KDM4ERAB9ALMNAKMT2AALDH1A1 | |
| SCHEMBL485566 | 0.83 | SHMT1 (0.43) | KDM4ENPC1RAB9APKMSLC6A4 | |
| SCHEMBL485707 | 0.77 | ALOX5AP (0.51) | KDM4ERAB9ALMNAKMT2AALDH1A1 | |
| Formic Acid SCHEMBL27713056 | 0.77 | ALOX5AP (0.48) | KDM4ERAB9ALMNAKMT2AALDH1A1 | |
| SCHEMBL486100 | 0.76 | RAB9A (0.44) | KDM4ENPC1RAB9APKMLMNA | |
| SCHEMBL485800 | 0.76 | KMT2A (0.49) | KDM4ENPC1RAB9ALMNAKMT2A | |
| Formic Acid SCHEMBL27712967 | 0.75 | KMT2A (0.55) | KMT2AALDH1A1MEN1GAA | |
| Formic Acid SCHEMBL27713038 | 0.75 | PIN1 (0.42) | KDM4ENPC1RAB9APKMLMNA | |
| SCHEMBL486088 | 0.74 | MRGPRX4 (0.56) | KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836158-B1 | FUSED BICYCLIC CARBOXAMIDE DERIVATIVES FOR USE AS CXCR2 INHIBITORS IN THE TREATMENT OF INFLAMMATION | SANOFI AVENTIS DEUTSCHLAND (DE) | 2012-02-01 | — | — | EP | claimed |