SCHEMBL4858742

SCHEMBL4858742

CCc1ccc(Cc2c([Si](C)(C)C(C)(C)C)n[nH]c2C)cc1

nearest known ligand 0.42

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 6/20 0.42
SLC5A1 P13866 5/20 0.42
AR P10275 1/20 0.41
MEN1 O00255 1/20 0.40
LMNA P02545 1/20 0.40
KMT2A Q03164 1/20 0.40
NOTUM Q6P988 1/20 0.34
APOBEC3G Q9HC16 1/20 0.33
TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2050645 0.82 SLC5A2 (0.47) SLC5A2SLC5A1NOTUM
SCHEMBL4854547 0.68 RAB9A (0.40) ARMEN1LMNAKMT2A
SCHEMBL4860259 0.65 SLC5A1 (0.47) SLC5A2SLC5A1ARMEN1LMNA
SCHEMBL13313003 0.64 LMNA (0.66) SLC5A2SLC5A1ARMEN1LMNA
SCHEMBL2047194 0.64 SMN1; SMN2 (0.38) MEN1LMNAKMT2A
SCHEMBL156171 0.63 GPR84 (0.43) SLC5A2SLC5A1ARMEN1LMNA
SCHEMBL4230856 0.62 LMNA (0.62) ARMEN1LMNAKMT2A
SCHEMBL22197860 0.62 MEN1 (0.62) ARMEN1LMNAKMT2AAPOBEC3G
SCHEMBL155106 0.62 ALDH1A1 (0.41) SLC5A2SLC5A1ARMEN1LMNA
SCHEMBL26100801 0.62 LMNA (0.62) ARMEN1LMNAKMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7439232-B2 Heteroaryl 5-thio-β-D-glucopyranoside derivatives and therapeutic agents for diabetes containing the same TAISHO PHARMACEUTICAL CO., LTD. (JP) 2008-10-21 US disclosed
US-20060194809-A1 Heteroaryl 5-thio-beta-d-gucopyranoside derivatives and therapeutic agents for diabetes containing the same TAISHO PHARMACEUTICAL CO., LTD. (JP) 2006-08-31 US disclosed
EP-1609799-A1 HETEROARYL 5-THIO-BETA-D-GLUCOPYRANOSIDE DERIVATIVES AND REMEDIES FOR DIABETES CONTAINING THE SAME TAISHO PHARMACEUTICAL CO., LTD (JP) 2005-12-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060194809-A1 Heteroaryl 5-thio-beta-d-gucopyranoside derivatives and therapeutic agents for diabetes containing the same SLC5A2, SLC5A1, UGGT1 SLC5A2 1/4885SLC5A1 2/4885AR 3255/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.