Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 8/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | STING1 | Q86WV6 | 5/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | BCL2 | P10415 | 2/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.37 |
| ▸ | BAD | Q92934 | 2/20 | 0.37 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.36 |
| ▸ | OGG1 | O15527 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9567940 | 0.80 | MCL1 (0.49) | MCL1MAPK1GPR35KDM4EALDH1A1 | |
| SCHEMBL17866243 | 0.79 | MCL1 (0.43) | MCL1MAPK1STING1GPR35KDM4E | |
| SCHEMBL20937648 | 0.74 | MCL1 (0.58) | MCL1MAPK1KDM4EALDH1A1GLA | |
| Hydrochloric Acid SCHEMBL8548770 | 0.72 | HTR1A (0.45) | MCL1MAPK1KDM4EALDH1A1HPGD | |
| SCHEMBL14894804 | 0.72 | GPR35 (0.46) | MCL1MAPK1STING1GPR35BCL2L1 | |
| SCHEMBL6614808 | 0.71 | MCL1 (0.45) | MCL1MAPK1STING1GPR35KDM4E | |
| SCHEMBL8545089 | 0.69 | DRD2 (0.46) | MAPK1GAATSHRL3MBTL1 | |
| SCHEMBL1179867 | 0.68 | CLCN2 (0.44) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL28456462 | 0.68 | GPR35 (0.39) | GPR35KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL3911188 | 0.67 | MAPK1 (0.49) | MCL1MAPK1STING1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090860-A1 | Retinoid x receptor modulators | GARDINIER KEVIN M | 2008-04-17 | — | — | US | disclosed |
| US-7348359-B2 | Retinoid X receptor modulators | ELI LILLY AND COMPANY (US) | 2008-03-25 | — | — | US | disclosed |
| EP-1373240-B1 | RETINOID X RECEPTOR MODULATORS | LILLY CO ELI (US) | 2005-06-15 | — | — | EP | disclosed |
| US-20040167160-A1 | Retinoid x receptor modulators | LIGAND PHARMACEUTICALS INCORPORATED | 2004-08-26 | — | — | US | disclosed |
| EP-1373240-A2 | RETINOID X RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002071827-A2 | RETINOID X RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2002-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167160-A1 | Retinoid x receptor modulators | RXRA, RXRG, RXRB | MCL1 4289/4885MAPK1 3920/4885STING1 4751/4885 |
| US-20080090860-A1 | Retinoid x receptor modulators | RXRA, RXRG, RXRB | MCL1 4204/4885MAPK1 3711/4885STING1 4764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.