Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 12/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 5/20 | 0.42 |
| ▸ | CYP2E1 | P05181 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30473120 | 0.74 | CYP2A6 (1.00) | CYP2A6CYP3A4ALDH1A1CYP1A2KDM4E | |
| SCHEMBL120088 | 0.74 | CYP2A6 (1.00) | CYP2A6CYP3A4ALDH1A1CYP1A2KDM4E | |
| SCHEMBL29419014 | 0.74 | CYP2A6 (1.00) | CYP2A6CYP3A4ALDH1A1CYP1A2KDM4E | |
| SCHEMBL7037516 | 0.73 | MAPT (0.48) | CYP3A4ALDH1A1CYP1A2KDM4ELMNA | |
| SCHEMBL28275760 | 0.71 | CYP2A6 (0.94) | CYP2A6CYP3A4ALDH1A1CYP1A2KDM4E | |
| Benzene SCHEMBL27934930 | 0.71 | CYP2A6 (0.94) | CYP2A6CYP3A4ALDH1A1CYP1A2KDM4E | |
| SCHEMBL28247322 | 0.71 | CYP2A6 (0.94) | CYP2A6CYP3A4ALDH1A1CYP1A2KDM4E | |
| SCHEMBL27812368 | 0.71 | CYP2A6 (0.94) | CYP2A6CYP3A4ALDH1A1CYP1A2KDM4E | |
| SCHEMBL28301145 | 0.71 | CYP2A6 (0.94) | CYP2A6CYP3A4ALDH1A1CYP1A2KDM4E | |
| Hydrochloric Acid SCHEMBL4831090 | 0.71 | CYP2A6 (0.94) | CYP2A6CYP3A4ALDH1A1CYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332476-B2 | Pyridyl substituted ketolide antibiotics | NOVARTIS AG (CH) | 2008-02-19 | — | — | US | disclosed |
| US-7163924-B2 | Ketolide derivatives | CHIRON CORPORATION (US) | 2007-01-16 | — | — | US | disclosed |
| EP-1670808-A1 | ANTIMICROBIAL DERIVATIVES | CHIRON CORPORATION (US) | 2006-06-21 | — | — | EP | disclosed |
| EP-1618120-A2 | NOVEL KETOLIDE DERIVATIVES | CHIRON CORPORATION (US) | 2006-01-25 | — | — | EP | disclosed |
| EP-1618119-A2 | PYRIDYL SUBSTITUTED KETOLIDE ANTIBIOTICS | CHIRON CORPORATION (US) | 2006-01-25 | — | — | EP | disclosed |
| US-20050153905-A1 | Novel ketolide derivatives | CHIRON CORPORATION (US) | 2005-07-14 | — | — | US | disclosed |
| US-20050101548-A1 | Antimicrobial derivatives | LIN XIAODONG (US) | 2005-05-12 | — | — | US | disclosed |
| WO-2005028493-A1 | ANTIMICROBIAL DERIVATIVES | CHIRON CORPORATION (US) | 2005-03-31 | — | — | WO | disclosed |
| US-20050009764-A1 | Pyridyl substituted ketolide antibiotics | CHIRON CORPORATION (US) | 2005-01-13 | — | — | US | disclosed |
| WO-2004096822-A2 | PYRIDYL SUBSTITUTED KETOLIDE ANTIBIOTICS | CHIRON CORPORATION (US) | 2004-11-11 | — | — | WO | disclosed |
| US-20030125266-A1 | C12 Modified erythromycin macrolides and ketolides having antibacterial activity | CHU DANIEL (US) | 2003-07-03 | — | — | US | disclosed |
| WO-2003004509-A2 | C12 MODIFIED ERYTHROMYCIN MACROLIDES AND KETOLIDES HAVING ANTIBACTERIAL ACTIVITY | CHIRON CORPORATION (US) | 2003-01-16 | — | — | WO | disclosed |
| US-20020161029-A1 | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-10-31 | — | — | US | disclosed |
| US-6413981-B1 | DRUG-RESISTANT GRAM POSITIVE AND GRAM NEGATIVE BACTERIA; PNEUMONIA; INFECTIONS OF UPPER AND LOWER RESPIRATORY TRACT, SKIN, SOFT TISSUE, BONES AND JOINTS | ORTHO-MCNEIL PHARAMCEUTICAL, INC. | 2002-07-02 | — | — | US | disclosed |
| EP-1206469-A1 | ANTIBACTERIAL HETEROBICYCLIC SUBSTITUTED PHENYL OXAZOLIDINONES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001042242-A1 | ANTIBACTERIAL HETEROBICYCLIC SUBSTITUTED PHENYL OXAZOLIDINONES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-06-14 | — | — | WO | disclosed |
| US-5750544-A | CARDIOVASCULAR DISORDERS; ANTIISCHEMIC AGENTS; BRAIN DISORDERS; ANTIASTHMA AGENTS; ANTIINFLAMMATOREY AGENTS; ANTIULCER AGENTS; SKIN DISORDERS; ANTALLERGENS | ONO PHARMACEUTICALS CO., LTD. (JP) | 1998-05-12 | — | — | US | disclosed |
| US-5534536-A | INHIBITORS OF THROMBOXANE A2 SYNTHETASE, 5-LIPOXYGENASE; SCAVENGERS OF ACTIVE OXYGEN SPECIES | ONO PHARMACEUTICALS CO. LTD. (JP) | 1996-07-09 | — | — | US | disclosed |
| EP-0640609-A1 | Fused phenol derivatives having inhibitory activity on TXA2 synthetase, and 5-lipoxygenase and scavenging activity on oxygen species | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-03-01 | — | — | EP | disclosed |
| US-5246914-A | Fungicides and plant growth regulators | BASF AKTIENGESELLSCHAFT (DE) | 1993-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020161029-A1 | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods | OXA1L, NDUFS3, CYCS | CYP2A6 461/4885CYP3A4 127/4885ALDH1A1 1644/4885 |
| US-20050009764-A1 | Pyridyl substituted ketolide antibiotics | PKLR, KHK, PGD | CYP2A6 57/4885CYP3A4 30/4885ALDH1A1 2876/4885 |
| US-20030125266-A1 | C12 Modified erythromycin macrolides and ketolides having antibacterial activity | MRPL21, CYP51A1, CEL | CYP2A6 68/4885CYP3A4 120/4885ALDH1A1 4150/4885 |
| US-20050153905-A1 | Novel ketolide derivatives | KHK, CYP51A1, SI | CYP2A6 110/4885CYP3A4 73/4885ALDH1A1 1182/4885 |
| US-20050101548-A1 | Antimicrobial derivatives | CFTR, VIP, Q6ZSR9 | CYP2A6 653/4885CYP3A4 113/4885ALDH1A1 2531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.