Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GNRHR | P30968 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4866686 | 0.92 | MAPT (0.44) | MAPTSMN1; SMN2TP53ALDH1A1NPSR1 | |
| SCHEMBL4866971 | 0.91 | ADORA2B (0.44) | MAPTSMN1; SMN2TP53ALDH1A1DCTPP1 | |
| SCHEMBL4866426 | 0.90 | ALDH1A1 (0.46) | MAPTALDH1A1HPGDL3MBTL1TSHR | |
| SCHEMBL4864036 | 0.90 | DCTPP1 (0.43) | MAPTSMN1; SMN2ALDH1A1DCTPP1GABRA5 | |
| SCHEMBL4867853 | 0.89 | MAPT (0.42) | MAPTSMN1; SMN2TP53ALDH1A1DCTPP1 | |
| SCHEMBL4889396 | 0.86 | ADORA2B (0.43) | MAPTSMN1; SMN2TP53GNRHRADORA2A | |
| SCHEMBL4767904 | 0.85 | MAPT (0.44) | MAPTSMN1; SMN2TP53ALDH1A1NPSR1 | |
| SCHEMBL4867838 | 0.84 | ADORA2B (0.40) | MAPTSMN1; SMN2TP53ALDH1A1DCTPP1 | |
| SCHEMBL4868188 | 0.83 | DCTPP1 (0.38) | MAPTSMN1; SMN2DCTPP1GABRA5L3MBTL1 | |
| SCHEMBL4862736 | 0.82 | PDE1A (0.40) | MAPTSMN1; SMN2TP53ALDH1A1DCTPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449473-B2 | Substituted pyrrolo[3,2-d]pyrimidin-2,4-diones as A2b adenosine receptor antagonists | CV THERAPEUTICS, INC. (US) | 2008-11-11 | — | — | US | disclosed |
| US-20050119287-A1 | A2B adenosine receptor antagonists | GILEAD PALO ALTO, INC. | 2005-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119287-A1 | A2B adenosine receptor antagonists | ADORA2B, ADORA2A, ADORA3 | MAPT 4503/4885SMN1; SMN2 3995/4885TP53 3718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.