Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 3/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.40 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | PDE6D | O43924 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4867858 | 0.90 | PDE1A (0.39) | PDE1APDE1BPDE1CDCTPP1GABRA5 | |
| SCHEMBL4866693 | 0.87 | ADORA2A (0.38) | PDE1APDE1BPDE1CDCTPP1GABRA5 | |
| SCHEMBL4864036 | 0.86 | DCTPP1 (0.43) | PDE1APDE1BPDE1CDCTPP1GABRA5 | |
| SCHEMBL4767913 | 0.85 | MAPT (0.43) | PDE1APDE1BPDE1CDCTPP1ADORA3 | |
| SCHEMBL4767908 | 0.85 | MAPT (0.43) | PDE1APDE1BPDE1CDCTPP1ADORA3 | |
| SCHEMBL4889399 | 0.85 | NPBWR1 (0.41) | PDE1APDE1BPDE1CDCTPP1NPBWR1 | |
| SCHEMBL4862734 | 0.82 | MAPT (0.44) | DCTPP1GABRA5SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL4790612 | 0.82 | DCTPP1 (0.42) | PDE1APDE1BPDE1CDCTPP1ADORA3 | |
| SCHEMBL4866434 | 0.82 | BRD4 (0.38) | DCTPP1ALDH1A1 | |
| SCHEMBL4769024 | 0.79 | ADORA2B (0.43) | PDE1APDE1BPDE1CGABRA5ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449473-B2 | Substituted pyrrolo[3,2-d]pyrimidin-2,4-diones as A2b adenosine receptor antagonists | CV THERAPEUTICS, INC. (US) | 2008-11-11 | — | — | US | disclosed |
| US-20050119287-A1 | A2B adenosine receptor antagonists | GILEAD PALO ALTO, INC. | 2005-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119287-A1 | A2B adenosine receptor antagonists | ADORA2B, ADORA2A, ADORA3 | PDE1A 912/4885PDE1B 545/4885PDE1C 1496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.