Sugi Predict

Sugi Predict / Compounds / SCHEMBL4865137

SCHEMBL4865137

SCHEMBL4865137

CCOC(=O)CC(=O)c1cc(OC)c(OC)c(OC)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 1.00
▸ KMT2A Q03164 3/20 1.00
▸ MEN1 O00255 2/20 1.00
▸ KDM4E B2RXH2 2/20 1.00
▸ GAA P10253 2/20 0.51
▸ TP53 P04637 1/20 0.50
▸ MAPK1 P28482 1/20 0.50
▸ L3MBTL1 Q9Y468 1/20 0.49
▸ HPGD P15428 2/20 0.47
▸ TSHR P16473 2/20 0.47
▸ CYP3A4 P08684 1/20 0.47
▸ CYP2D6 P10635 1/20 0.47
▸ THPO P40225 1/20 0.47
▸ MTOR P42345 1/20 0.47
▸ SCN1A P35498 1/20 0.47
▸ SCN2A Q99250 1/20 0.47
▸ SCN3A Q9NY46 1/20 0.47
▸ MAPT P10636 1/20 0.46
▸ APOBEC3A P31941 1/20 0.46
▸ APOBEC3G Q9HC16 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12417592 0.92 ALDH1A1 (0.86) ALDH1A1KMT2AMEN1KDM4EGAA
SCHEMBL7120174 0.90 ALDH1A1 (0.81) ALDH1A1KMT2AMEN1KDM4EGAA
SCHEMBL20307621 0.87 ALDH1A1 (0.77) ALDH1A1KMT2AMEN1KDM4EGAA
SCHEMBL9729410 0.86 KMT2A (0.76) ALDH1A1KMT2AMEN1KDM4EGAA
SCHEMBL25197137 0.84 ALDH1A1 (0.73) ALDH1A1KMT2AMEN1KDM4EGAA
SCHEMBL12378901 0.84 ALDH1A1 (0.73) ALDH1A1KMT2AMEN1KDM4EGAA
SCHEMBL7046987 0.84 ALDH1A1 (0.72) ALDH1A1KMT2AMEN1KDM4EGAA
SCHEMBL2848397 0.83 MEN1 (0.70) ALDH1A1KMT2AMEN1KDM4EGAA
SCHEMBL31314527 0.83 MEN1 (0.70) ALDH1A1KMT2AMEN1KDM4EGAA
SCHEMBL12378894 0.81 MEN1 (0.68) ALDH1A1KMT2AMEN1KDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250163066-A1 PROTACs of MALT1 TEGID THERAPEUTICS, INC. 2025-05-22 — — US disclosed
EP-4482497-A2 PROTACS OF MALT1 Tegid Therapeutics, Inc. (US) 2025-01-01 — — EP disclosed
WO-2023164175-A2 PROTACS OF MALT1 TEGID THERAPEUTICS, INC. (US) 2023-08-31 — — WO disclosed
WO-2023164175-A2 PROTACS OF MALT1 TEGID THERAPEUTICS, INC. (US) 2023-08-31 — — WO disclosed
US-20230113225-A1 INHIBITORS OF MICROBIALLY INDUCED AMYLOID AXIAL THERAPEUTICS, INC. (US) 2023-04-13 — — US disclosed
US-20230103887-A1 INHIBITORS OF MICROBIALLY INDUCED AMYLOID AXIAL THERAPEUTICS, INC. (US) 2023-04-06 — — US disclosed
CN-114057666-B Synthesis method of 4, 5-disubstituted-2-aminothiazole compound 沈阳药科大学 2023-02-07 — — CN disclosed
US-11505528-B2 Inhibitors of microbially induced amyloid AXIAL THERAPEUTICS, INC. (US) 2022-11-22 — — US disclosed
US-11505528-B2 Inhibitors of microbially induced amyloid AXIAL THERAPEUTICS, INC. (US) 2022-11-22 — — US disclosed
CN-114057666-A Synthesis method of 4, 5-disubstituted-2-aminothiazole compound 沈阳药科大学 2022-02-18 — — CN disclosed
US-6916798-B2 Inhibitors of GSK-3 and uses thereof VERTEX PHARMACEUTICALS INCORPORATED (US) 2005-07-12 — — US disclosed
US-20040024040-A1 Inhibitors of GSK-3 and uses thereof VERTEX PHARMACEUTICALS INCORPORATED 2004-02-05 — — US disclosed
WO-2003011287-A1 PYRAZOLON DERIVATIVES AS INHIBITORS OF GSK-3 VERTEX PHARMACEUTICALS INCORPORATED (US) 2003-02-13 — — WO disclosed
CN-1052481-C Platelet activating factor antagonist and preparation thereof MILITARY MEDICAL UNIV NO 2 PLA (CN) 2000-05-17 — — CN disclosed
CN-1142495-A Platelet activating factor antagonist and preparation thereof MILLITARY MEDICAL UNIV NO 2 P (CN) 1997-02-12 — — CN disclosed
US-4824851-A Pyrimidones as cardiotonic, anti hypertensive, cerebrovascular vasodilator and anti-platelet agents FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1989-04-25 — — US disclosed
EP-0123402-B1 PYRIMIDINE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1988-09-07 — — EP disclosed
US-4746664-A Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1988-05-24 — — US disclosed
US-4612376-A Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1986-09-16 — — US disclosed
EP-0123402-A2 Pyrimidine derivatives, preparation thereof and use thereof FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1984-10-31 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230103887-A1 INHIBITORS OF MICROBIALLY INDUCED AMYLOID SNCA, PARK7, PRNP ALDH1A1 4090/4885KMT2A 4786/4885MEN1 4376/4885
US-11505528-B2 Inhibitors of microbially induced amyloid SNCA, PARK7, PRNP ALDH1A1 4090/4885KMT2A 4786/4885MEN1 4376/4885
US-20250163066-A1 PROTACs of MALT1 MALT1, BCL3, BCL9 ALDH1A1 3679/4885KMT2A 557/4885MEN1 656/4885
US-20230113225-A1 INHIBITORS OF MICROBIALLY INDUCED AMYLOID SNCA, PARK7, PRNP ALDH1A1 4129/4885KMT2A 4816/4885MEN1 4393/4885
US-20040024040-A1 Inhibitors of GSK-3 and uses thereof GSK3B, AURKC, GSK3A ALDH1A1 3536/4885KMT2A 688/4885MEN1 1190/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.