Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.81 |
| ▸ | MEN1 | O00255 | 2/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.81 |
| ▸ | BPTF | Q12830 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TPMT | P51580 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4865137 | 0.90 | ALDH1A1 (1.00) | ALDH1A1KMT2AMEN1KDM4EGAA | |
| SCHEMBL12417592 | 0.86 | ALDH1A1 (0.86) | ALDH1A1KMT2AMEN1KDM4EGAA | |
| SCHEMBL7129669 | 0.82 | BPTF (0.58) | ALDH1A1KMT2AMEN1KDM4EBPTF | |
| SCHEMBL20307621 | 0.81 | ALDH1A1 (0.77) | ALDH1A1KMT2AMEN1KDM4EGAA | |
| SCHEMBL12378901 | 0.78 | ALDH1A1 (0.73) | ALDH1A1KMT2AMEN1KDM4EGAA | |
| SCHEMBL9660136 | 0.77 | BPTF (0.53) | ALDH1A1KMT2AMEN1KDM4EBPTF | |
| SCHEMBL9729410 | 0.77 | KMT2A (0.76) | ALDH1A1KMT2AMEN1KDM4EGAA | |
| SCHEMBL2848397 | 0.77 | MEN1 (0.70) | ALDH1A1KMT2AMEN1KDM4EGAA | |
| SCHEMBL31314527 | 0.77 | MEN1 (0.70) | ALDH1A1KMT2AMEN1KDM4EGAA | |
| SCHEMBL28534372 | 0.76 | TPMT (0.53) | ALDH1A1KMT2AMEN1KDM4EBPTF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1136198-C | Novel benzyl pyrimidines | ��������ҩ�ɷ�����˾ | 2004-01-28 | — | — | CN | disclosed |
| EP-0793656-B1 | NOVEL BENZYL PYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2003-03-26 | — | — | EP | disclosed |
| US-5763450-A | BACTERICIDES; TREATMENT OF INFECTIOUS DISEASES | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |
| CN-1166831-A | Novel benzyl pyrimidines | HOFFMANN LA ROCHE (CH) | 1997-12-03 | — | — | CN | disclosed |
| EP-0793656-A1 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016046-A2 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-05-30 | — | — | WO | disclosed |