Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5911326 | 0.80 | SMN1; SMN2 (0.36) | GRM5KMT2AMEN1SMN1; SMN2BRD4 | |
| SCHEMBL5175535 | 0.75 | L3MBTL1 (0.44) | KMT2AMEN1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL230546 | 0.74 | CTRB1 (0.36) | — | |
| SCHEMBL4258317 | 0.72 | CTRB1 (0.33) | — | |
| SCHEMBL5004808 | 0.72 | PLA2G10 (0.39) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL388934 | 0.72 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL3712470 | 0.71 | TSHR (0.40) | KMT2AMEN1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2237588 | 0.71 | P2RX7 (0.62) | P2RX7CTSAGRM5KMT2AMEN1 | |
| SCHEMBL133894 | 0.70 | MEN1 (0.36) | KMT2AMEN1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL5742539 | 0.70 | PTPN1 (0.41) | KMT2AMEN1SMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420685-B2 | 2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors | SK CHEMICALS CO., LTD. (KR) | 2013-04-16 | — | — | US | disclosed |
| US-20080319022-A1 | 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors | IN2GEN CO., LTD. (KR) | 2008-12-25 | — | — | US | disclosed |
| US-7407958-B2 | 2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors | SK CHEMICALS CO., LTD. (KR) | 2008-08-05 | — | — | US | disclosed |
| EP-1620426-A1 | 2-PYRIDYL SUBSTITUTED IMIDAZOLES AS ALK5 AND/OR ALK4 INHIBITORS | In2gen Co., Ltd. (KR) | 2006-02-01 | — | — | EP | disclosed |
| US-20050261299-A1 | 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors | IN2GEN CO., LTD. (KR) | 2005-11-24 | — | — | US | disclosed |
| WO-2005103028-A1 | 2-PYRIDYL SUBSTITUTED IMIDAZOLES AS ALK5 AND/OR ALK4 INHIBITORS | IN2GEN CO., LTD (KR) | 2005-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261299-A1 | 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors | ACVR1, ACVRL1, ACVR1B | P2RX7 2936/4885CTSA 3735/4885GRM5 2522/4885 |
| US-20080319022-A1 | 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors | ALK, ERBB4, ACVR1 | P2RX7 1674/4885CTSA 4018/4885GRM5 796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.