Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22729817 | 0.78 | PARP1 (0.34) | CYP1A2PARP1KDM4EALDH1A1HPGD | |
| SCHEMBL31309174 | 0.66 | PARP1 (0.39) | CYP1A2PARP1KDM4EALDH1A1HPGD | |
| SCHEMBL7913110 | 0.66 | NPC1 (0.47) | CYP1A2PARP1KDM4EALDH1A1HPGD | |
| SCHEMBL14341735 | 0.65 | KDM4E (0.37) | CYP1A2PARP1KDM4EALDH1A1HPGD | |
| SCHEMBL15382212 | 0.65 | ALDH1A1 (0.33) | KDM4EALDH1A1LMNAKMT2A | |
| SCHEMBL14341744 | 0.64 | KDM4E (0.40) | CYP1A2PARP1KDM4EALDH1A1HPGD | |
| SCHEMBL16081467 | 0.63 | SMN1; SMN2 (0.41) | KDM4EALDH1A1HPGDTSHRLMNA | |
| SCHEMBL16738968 | 0.62 | KDM4E (0.46) | CYP1A2PARP1KDM4EALDH1A1HPGD | |
| SCHEMBL4244986 | 0.61 | USP2 (0.45) | CYP1A2PARP1KDM4EALDH1A1HPGD | |
| SCHEMBL545028 | 0.61 | KDM4E (0.50) | CYP1A2PARP1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4005100-A | ANTIDIABETIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1977-01-25 | — | — | US | claimed |
| WO-2023212219-A1 | TRICYCLIC PARP1 INHIBITORS AND USES THEREOF | XINTHERA, INC. (US) | 2023-11-02 | — | — | WO | disclosed |
| US-20080090836-A1 | Pyrazole Compounds Useful In The Treatment Of Inflammation | BIOLIPOX AB (SE) | 2008-04-17 | — | — | US | disclosed |
| US-20070225318-A1 | Pyrazole Compounds Useful In The Treatment Of Inflammation | BIOLIPOX AB (SE) | 2007-09-27 | — | — | US | disclosed |
| US-4005100-A | ANTIDIABETIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1977-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225318-A1 | Pyrazole Compounds Useful In The Treatment Of Inflammation | ALOX15, ALOX15B, ALOX12 | CYP1A2 38/4885PARP1 2047/4885KDM4E 3533/4885 |
| US-20080090836-A1 | Pyrazole Compounds Useful In The Treatment Of Inflammation | ALOX15, ALOX15B, ALOX12 | CYP1A2 50/4885PARP1 1606/4885KDM4E 3158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.