SCHEMBL487226

SCHEMBL487226

CS(=O)(=O)c1ccc(S)cc1

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ENPP2 Q13822 2/20 0.56
PTGS2 P35354 10/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL22687010 0.97 ENPP2 (0.54) ENPP2PTGS2
Water SCHEMBL28883186 0.97 ENPP2 (0.54) ENPP2PTGS2
SCHEMBL10058341 0.93 PTGS2 (0.52) ENPP2PTGS2
SCHEMBL4278822 0.89 PTGS2 (0.58) PTGS2
SCHEMBL13898960 0.87 SMN1; SMN2 (0.48) ENPP2PTGS2
SCHEMBL2376239 0.85 ENPP2 (0.72) ENPP2PTGS2
SCHEMBL7595976 0.85 ENPP2 (0.48) ENPP2PTGS2
Ether SCHEMBL22687009 0.85 ENPP2 (0.43) ENPP2PTGS2
SCHEMBL14016001 0.82 PTGS2 (0.54) ENPP2PTGS2
SCHEMBL2642467 0.78 ENPP2 (0.56) ENPP2PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 416 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9406509-B2 Deposition of heteroatom-doped carbon films APPLIED MATERIALS, INC. (US) 2016-08-02 US claimed
US-20150206739-A1 DEPOSITION OF HETEROATOM-DOPED CARBON FILMS APPLIED MATERIALS, INC. 2015-07-23 US claimed
EP-1598349-B1 NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES MSD KK (JP) 2011-07-27 EP claimed
US-20030125329-A1 Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity G.D. SEARLE & CO. 2003-07-03 US claimed
US-20030125328-A1 Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity G.D. SEARLE & CO. (US) 2003-07-03 US claimed
US-20030119833-A1 Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity G.D. SEARLE & CO. 2003-06-26 US claimed
US-20030114454-A1 Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity G.D. SEARLE & CO. (US) 2003-06-19 US claimed
US-20030109528-A1 Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity G.D. SEARLE & CO. (US) 2003-06-12 US claimed
US-20030105100-A1 Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity G.D. SEARLE & CO. 2003-06-05 US claimed
US-20030100559-A1 Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity G.D. SEARLE & CO. 2003-05-29 US claimed
US-6139589-A HAIR DYES L'OREAL S.A. (FR) 2000-10-31 US claimed
US-6063136-A Compositions containing pyrrolo-oxazole couplers for dyeing keratin fibers and dyeing methods L'OREAL S.A. (FR) 2000-05-16 US claimed
WO-2000018721-A1 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL TERTIARY-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY MONSANTO COMPANY (US) 2000-04-06 WO claimed
US-5116990-A MAGENTA DYE-FORMING COUPLER FUJI PHOTO FILM CO., LTD. (JP) 1992-05-26 US claimed
US-5084478-A Antiandrogens for treatment of prostatic disease, acne, hirsutism or seborrhoea IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-01-28 US claimed
EP-0193303-B1 ALKENE, ALKYNE OR CYCLOALKYLENE DERIVATIVES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1991-10-23 EP claimed
EP-0170164-B1 SILVER HALIDE COLOR PHOTOGRAPHIC LIGHT-SENSITIVE MATERIAL FUJI PHOTO FILM CO., LTD. (JP) 1988-10-05 EP claimed
EP-0193303-A2 Alkene, alkyne or cycloalkylene derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1986-09-03 EP claimed
US-H122-H PYRAZOLOAZOLE-TYPE MAGENTA COUPLER DISPERSED IN A HIGH-BOILING PHOSPHATE SOLVENT FUJI PHOTO FILM CO., LTD. (JP) 1986-09-02 US claimed
EP-0170164-A2 Silver halide color photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JP) 1986-02-05 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030114454-A1 Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity CETP, MTTP, LCAT ENPP2 1317/4885PTGS2 3720/4885
US-20030125328-A1 Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity CETP, MTTP, LCAT ENPP2 1317/4885PTGS2 3720/4885
US-20030105100-A1 Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity CETP, MTTP, LCAT ENPP2 1317/4885PTGS2 3720/4885
US-20030109528-A1 Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity CETP, MTTP, LCAT ENPP2 1317/4885PTGS2 3720/4885
US-20030119833-A1 Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity CETP, MTTP, LCAT ENPP2 1317/4885PTGS2 3720/4885
US-20030100559-A1 Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity CETP, MTTP, LCAT ENPP2 1317/4885PTGS2 3720/4885
US-20030125329-A1 Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity CETP, MTTP, LCAT ENPP2 1317/4885PTGS2 3720/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.