Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.48 |
| ▸ | HTT | P42858 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11547843 | 0.89 | HTT (0.58) | SMN1; SMN2HTTLMNAALDH1A1ENPP2 | |
| SCHEMBL487226 | 0.87 | ENPP2 (0.56) | ENPP2PTGS2 | |
| Water SCHEMBL28883186 | 0.84 | ENPP2 (0.54) | ENPP2PTGS2 | |
| Water SCHEMBL22687010 | 0.84 | ENPP2 (0.54) | ENPP2PTGS2 | |
| SCHEMBL27090263 | 0.83 | HTT (0.55) | SMN1; SMN2HTTLMNAALDH1A1NPC1 | |
| SCHEMBL8941654 | 0.83 | PTGS2 (0.56) | SMN1; SMN2HTTLMNAALDH1A1ENPP2 | |
| SCHEMBL7359540 | 0.81 | SOS1 (0.64) | SMN1; SMN2HTTLMNAPTGS2TSHR | |
| SCHEMBL13814624 | 0.81 | HTT (0.63) | SMN1; SMN2HTTLMNAALDH1A1PTGS2 | |
| SCHEMBL8005674 | 0.81 | PKM (0.61) | PTGS2NPC1RAB9APTGS1 | |
| SCHEMBL2758531 | 0.81 | HTT (0.63) | SMN1; SMN2HTTLMNAALDH1A1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504537-B2 | Hydroxamic acid derivative and MMP inhibitor containing the same as active ingredient | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2009-03-17 | — | — | US | disclosed |
| US-7504537-B2 | Hydroxamic acid derivative and MMP inhibitor containing the same as active ingredient | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2009-03-17 | — | — | US | disclosed |