Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 5/20 | 0.50 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.50 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 3/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.38 |
| ▸ | ACACA | Q13085 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14688584 | 0.75 | RAB9A (0.68) | CYP1A2KDM4E | |
| SCHEMBL12614850 | 0.75 | S1PR3 (0.71) | S1PR3S1PR4S1PR2ALDH1A1S1PR1 | |
| SCHEMBL19195652 | 0.75 | S1PR3 (0.71) | S1PR3S1PR4S1PR2ALDH1A1S1PR1 | |
| SCHEMBL7129699 | 0.73 | ALDH1A1 (0.57) | S1PR3S1PR4S1PR2ALDH1A1S1PR1 | |
| SCHEMBL2339352 | 0.73 | S1PR2 (0.50) | S1PR3S1PR4S1PR2ALDH1A1CYP1A2 | |
| SCHEMBL27959751 | 0.72 | S1PR2 (0.46) | S1PR3S1PR4S1PR2ALDH1A1CYP1A2 | |
| SCHEMBL659350 | 0.71 | ACACB (0.50) | MMEACACBROCK1ROCK2ACACA | |
| SCHEMBL1179681 | 0.71 | KMT2A (0.61) | ALDH1A1KDM4E | |
| SCHEMBL566140 | 0.70 | ACACB (0.43) | ALDH1A1MMEACACBPIM1PIM3 | |
| SCHEMBL12477389 | 0.70 | ALDH1A1 (0.48) | ALDH1A1CYP1A2CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080064690-A1 | PYRAZOLE-AMIDES AND -SULFONAMIDES | ICAGEN, INC. (US) | 2008-03-13 | — | — | US | disclosed |
| US-7223782-B2 | Pyrazole-amides and -sulfonamides | ICAGEN, INC. (US) | 2007-05-29 | — | — | US | disclosed |
| US-20050049237-A1 | Pyrazole-amides and -sulfonamides | ICAGEN, INC. (US) | 2005-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064690-A1 | PYRAZOLE-AMIDES AND -SULFONAMIDES | SCN3A, TRPV3, HCN3 | S1PR3 187/4885S1PR4 563/4885S1PR2 522/4885 |
| US-20050049237-A1 | Pyrazole-amides and -sulfonamides | SCN3A, TRPV3, HCN3 | S1PR3 187/4885S1PR4 563/4885S1PR2 522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.