Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Orotic Acid SCHEMBL5651937 | 0.75 | LMNA (0.63) | SMN1; SMN2ALDH1A1LMNACYP2C19CA1 | |
| Chelidamic Acid SCHEMBL742928 | 0.74 | ALOX15 (1.00) | ALOX15NFKB1BLMSMN1; SMN2ALDH1A1 | |
| SCHEMBL28802808 | 0.70 | CA2 (0.42) | ALOX15NFKB1BLMSMN1; SMN2ALDH1A1 | |
| Orotic Acid SCHEMBL11903508 | 0.70 | ALDH1A1 (0.63) | SMN1; SMN2ALDH1A1LMNACYP2C19CA1 | |
| Orotic Acid SCHEMBL5148012 | 0.70 | LMNA (0.63) | SMN1; SMN2ALDH1A1LMNACYP2C19CA1 | |
| Orotic Acid SCHEMBL23859826 | 0.70 | LMNA (0.63) | SMN1; SMN2ALDH1A1LMNACYP2C19CA1 | |
| Orotic Acid SCHEMBL161884 | 0.70 | LMNA (0.63) | SMN1; SMN2ALDH1A1LMNACYP2C19CA1 | |
| Orotic Acid SCHEMBL896843 | 0.70 | LMNA (0.63) | SMN1; SMN2ALDH1A1LMNACYP2C19CA1 | |
| Orotic Acid SCHEMBL20518755 | 0.70 | LMNA (0.63) | SMN1; SMN2ALDH1A1LMNACYP2C19CA1 | |
| Orotic Acid SCHEMBL422601 | 0.70 | LMNA (0.63) | SMN1; SMN2ALDH1A1LMNACYP2C19CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080213400-A1 | Combinations of Chromium with Antidiabetics for Glucose Metabolism Disorders | AKESIS PHARMACEUTICALS (US) | 2008-09-04 | — | — | US | disclosed |
| US-20080181970-A1 | Combinations of Vanadium with Antidiabetics for Glucose Metabolism Disorders | AKESIS PHARMACEUTICALS (US) | 2008-07-31 | — | — | US | disclosed |
| US-20070293566-A1 | Combinations of vanadium with antidiabetics for glucose metabolism disorders | AKESIS PHARMACEUTICALS (US) | 2007-12-20 | — | — | US | disclosed |
| US-20070281042-A1 | Combinations of chromium with antidiabetics for glucose metabolism disorders | AKESIS PHARMACEUTICALS (US) | 2007-12-06 | — | — | US | disclosed |
| US-20070207218-A1 | Combinations of vanadium with antidiabetics for glucose metabolism disorders | AKESIS PHARMACEUTICALS (US) | 2007-09-06 | — | — | US | disclosed |
| US-20070197425-A1 | Combinations of chromium with antidiabetics for glucose metabolism disorders | AKESIS PHARMACEUTICALS (US) | 2007-08-23 | — | — | US | disclosed |
| US-20070196512-A1 | Combinations of vanadium with antidiabetics for glucose metabolism disorders | AKESIS PHARMACEUTICALS (US) | 2007-08-23 | — | — | US | disclosed |
| US-20070161540-A1 | Combinations of chromium or vanadium with antidiabetics for glucose metabolism disorders | AKESIS PHARMACEUTICALS (US) | 2007-07-12 | — | — | US | disclosed |
| US-20070092584-A1 | Combinations of chromium with antidiabetics for glucose metabolism disorders | AKESIS PHARMACEUTICALS (US) | 2007-04-26 | — | — | US | disclosed |
| US-20060252686-A1 | Combinations of chromium or vanadium with antidiabetics for glucose metabolism disorders | AKESIS PHARMACEUTICALS, INC. (US) | 2006-11-09 | — | — | US | disclosed |
| US-20060003981-A1 | Combinations of chromium or vanadium with antidiabetics for glucose metabolism disorders | FINE STUART A | 2006-01-05 | — | — | US | disclosed |
| US-20050282794-A1 | Combinations of chromium or vanadium with antidiabetics for glucose metabolism disorders | FINE STUART A | 2005-12-22 | — | — | US | disclosed |
| US-20050233946-A1 | Combinations of chromium or vanadium with antidiabetics for glucose metabolism disorders | FINE STUART A | 2005-10-20 | — | — | US | disclosed |
| US-20050233947-A1 | Combinations of chromium or vanadium with antidiabetics | FINE STUART A | 2005-10-20 | — | — | US | disclosed |
| US-20050187144-A1 | Combinations of chromium or vanadium with antidiabetics for glucose metabolism disorders | FINE STUART A (US) | 2005-08-25 | — | — | US | disclosed |
| EP-1113804-A2 | COMBINATIONS OF CHROMIUM OR VANADIUM WITH ANTIDIABETICS FOR GLUCOSE METABOLISM DISORDERS | Akesis Pharmaceuticals, Inc. (US) | 2001-07-11 | — | — | EP | disclosed |
| WO-2001003700-A1 | COMBINATION OF CHROMIUM AND VANADIUM FOR GLUCOSE METABOLISM DISORDERS | AKESIS PHARMACEUTICALS, INC. (US) | 2001-01-18 | — | — | WO | disclosed |
| WO-2000057721-A2 | EDIBLE SOLIDS FOR TREATMENT OF GLUCOSE METABOLISM DISORDERS | AKESIS PHARMACEUTICALS, INC. (US) | 2000-10-05 | — | — | WO | disclosed |
| WO-2000057729-A2 | BEVERAGES FOR TREATMENT OF GLUCOSE METABOLISM DISORDERS | AKESIS PHARMACEUTICALS, INC. (US) | 2000-10-05 | — | — | WO | disclosed |
| WO-2000015211-A2 | COMPOSITIONS OF CHROMIUM OR VANADIUM WITH ANTIDIABETICS FOR GLUCOSE METABOLISM DISORDERS | AKESIS PHARMACEUTICALS, INC. (US) | 2000-03-23 | — | — | WO | disclosed |