Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
| ▸ | PPARD | Q03181 | 1/20 | 0.56 |
| ▸ | PPARA | Q07869 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | TTR | P02766 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2846385 | 0.85 | ALDH1A1 (0.77) | ALDH1A1PPARGPPARDPPARACYP2D6 | |
| SCHEMBL4877099 | 0.84 | ALDH1A1 (0.56) | ALDH1A1PPARGPPARDPPARACYP2D6 | |
| SCHEMBL10371413 | 0.83 | KDM4E (0.70) | ALDH1A1PPARGPPARDPPARACYP2D6 | |
| SCHEMBL18244599 | 0.83 | ALDH1A1 (0.63) | ALDH1A1PPARGPPARDPPARACYP2D6 | |
| SCHEMBL3065052 | 0.82 | MAPT (0.41) | ALDH1A1PPARGPPARDPPARACYP2D6 | |
| SCHEMBL4523312 | 0.82 | GAA (0.41) | ALDH1A1PPARGPPARDPPARACYP2D6 | |
| SCHEMBL16141745 | 0.81 | ALDH1A1 (0.54) | ALDH1A1PPARGPPARDPPARACYP2D6 | |
| SCHEMBL185845 | 0.80 | CA2 (0.68) | ALDH1A1PPARGPPARDPPARACYP2D6 | |
| SCHEMBL30074670 | 0.80 | CA2 (0.68) | ALDH1A1PPARGPPARDPPARACYP2D6 | |
| SCHEMBL2523355 | 0.80 | GAA (0.45) | ALDH1A1PPARDTTRHPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10822349-B2 | Macrocyclic purines for the treatment of viral infections | Janssen Sciences Ireland Unlimited Company (IE) | 2020-11-03 | — | — | US | disclosed |
| US-20190330234-A1 | MACROCYCLIC PURINES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2019-10-31 | — | — | US | disclosed |
| US-10280180-B2 | Macrocyclic purines for the treatment of viral infections | JANSSEN SCIENCES IRELAND UC (IE) | 2019-05-07 | — | — | US | disclosed |
| EP-2872515-B1 | MACROCYCLIC PURINES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UC (IE) | 2016-06-08 | — | — | EP | disclosed |
| US-20150299221-A1 | MACROCYCLIC PURINES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland Unlimited Company (IE) | 2015-10-22 | — | — | US | disclosed |
| US-20150299221-A1 | MACROCYCLIC PURINES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland Unlimited Company (IE) | 2015-10-22 | — | — | US | disclosed |
| CN-102791667-B | Method for producing high purity aromatic methyl alcohol, and high purity aromatic methyl alcohol composition having excellent storage stability | UBE INDUSTRIES | 2014-11-05 | — | — | CN | disclosed |
| WO-2014009509-A1 | MACROCYCLIC PURINES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN R&D IRELAND (IE) | 2014-01-16 | — | — | WO | disclosed |
| EP-2540695-A1 | METHOD FOR PRODUCING HIGH PURITY AROMATIC METHYL ALCOHOL, AND HIGH PURITY AROMATIC METHYL ALCOHOL COMPOSITION HAVING EXCELLENT STORAGE STABILITY | Ube Industries, Ltd. (JP) | 2013-01-02 | — | — | EP | disclosed |
| US-20120323021-A1 | METHOD FOR PRODUCING A HIGH-PURITY AROMATIC METHYL ALCOHOL AND HIGH-PURITY AROMATIC METHYL ALCOHOL COMPOSITION HAVING EXCELLENT PRESERVATION STABILITY | UBE INDUSTRIES, LTD. (JP) | 2012-12-20 | — | — | US | disclosed |
| CN-102791667-A | Method for producing high purity aromatic methyl alcohol, and high purity aromatic methyl alcohol composition having excellent storage stability | UBE INDUSTRIES | 2012-11-21 | — | — | CN | disclosed |
| US-20080132477-A1 | Macrocyclic Compounds Useful as Bace Inhibitors | NOVARTIS AG (CH) | 2008-06-05 | — | — | US | disclosed |
| EP-1851208-A1 | MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS | Novartis AG (CH) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006074950-A1 | MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2006-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190330234-A1 | MACROCYCLIC PURINES FOR THE TREATMENT OF VIRAL INFECTIONS | PNP, HPRT1, UMPS | ALDH1A1 3148/4885PPARG 2289/4885PPARD 1462/4885 |
| US-10280180-B2 | Macrocyclic purines for the treatment of viral infections | PNP, HPRT1, UMPS | ALDH1A1 3148/4885PPARG 2289/4885PPARD 1462/4885 |
| US-20120323021-A1 | METHOD FOR PRODUCING A HIGH-PURITY AROMATIC METHYL ALCOHOL AND HIGH-PURITY AROMATIC METHYL ALCOHOL COMPOSITION HAVING EXCELLENT PRESERVATION STABILITY | ALKBH5, ALKBH2, ALKBH3 | ALDH1A1 186/4885PPARG 1124/4885PPARD 1326/4885 |
| US-20150299221-A1 | MACROCYCLIC PURINES FOR THE TREATMENT OF VIRAL INFECTIONS | PNP, HPRT1, UMPS | ALDH1A1 3148/4885PPARG 2289/4885PPARD 1462/4885 |
| US-20080132477-A1 | Macrocyclic Compounds Useful as Bace Inhibitors | BACE1, BACE2, APP | ALDH1A1 2631/4885PPARG 3280/4885PPARD 2784/4885 |
| US-10822349-B2 | Macrocyclic purines for the treatment of viral infections | PNP, HPRT1, UMPS | ALDH1A1 3148/4885PPARG 2289/4885PPARD 1462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.