Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.37 |
| ▸ | TUBB | P07437 | 2/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.37 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.37 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.37 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.37 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4878845 | 0.90 | NQO1 (0.45) | NQO1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4238902 | 0.78 | NQO1 (0.46) | NQO1TUBB4ATUBBTUBA3CTUBA1B | |
| Biphenyl SCHEMBL5178781 | 0.75 | HPGD (0.41) | NQO1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL31649350 | 0.74 | TUBB4A (0.43) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5178783 | 0.73 | ALDH1A1 (0.40) | NQO1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5950594 | 0.70 | NQO1 (0.46) | NQO1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1089895 | 0.68 | PKM (0.52) | KDM4EALDH1A1KMT2AMAPTNPC1 | |
| SCHEMBL3139546 | 0.68 | CYP2C9 (0.33) | KMT2ASMN1; SMN2 | |
| SCHEMBL7114732 | 0.68 | SMN1; SMN2 (0.47) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7889092 | 0.67 | NQO1 (0.53) | NQO1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071909-B1 | TWO-PHOTON OR HIGHER-ORDER ABSORBING OPTICAL MATERIALS | CALIFORNIA INST OF TECHN (US) | 2014-01-22 | — | — | EP | disclosed |
| US-8597549-B2 | Two-photon or higher-order absorbing optical materials for generation of reactive species | THE CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2013-12-03 | — | — | US | disclosed |
| US-20080283804-A1 | include a bridge of pi-conjugated bonds connecting electron donating or accepting groups; electronically excited upon absorption lead to formation of Lewis acidic species, Lewis basic species, radical species or ionic species; chromogens use in engineering, biological, and medicinal field | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2008-11-20 | — | — | US | disclosed |
| US-7235194-B2 | Two-photon or higher-order absorbing optical materials for generation of reactive species | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2007-06-26 | — | — | US | disclosed |
| EP-1071909-A4 | TWO-PHOTON OR HIGHER-ORDER ABSORBING OPTICAL MATERIALS | CALIFORNIA INST OF TECHN (US) | 2005-02-02 | — | — | EP | disclosed |
| US-20040110984-A1 | Two-photon or higher-order absorbing optical materials for generation of reactive species | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2004-06-10 | — | — | US | disclosed |
| US-6608228-B1 | Fluorenyl and dibenzosuberenyl moieties; efficient | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2003-08-19 | — | — | US | disclosed |
| EP-1071909-A1 | TWO-PHOTON OR HIGHER-ORDER ABSORBING OPTICAL MATERIALS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999053242-A1 | TWO-PHOTON OR HIGHER-ORDER ABSORBING OPTICAL MATERIALS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1999-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110984-A1 | Two-photon or higher-order absorbing optical materials for generation of reactive species | SLC43A1, SLC7A1, SLC7A5 | NQO1 51/4885TUBB4A 2012/4885TUBB 2755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.