Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1134032 | 0.95 | — | — | |
| Hydrochloric Acid SCHEMBL1278919 | 0.93 | ALOX15 (0.46) | MMP8ALOX15CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL4618149 | 0.88 | GAA (0.42) | MMP8ALOX15CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL4270735 | 0.83 | ALOX15 (0.38) | MMP8ALOX15CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL22747722 | 0.80 | ALOX15 (0.48) | MMP8ALOX15CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL8632493 | 0.80 | — | — | |
| SCHEMBL6591180 | 0.79 | PKM (0.47) | MMP8ALOX15CYP4F2CYP4A11ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10531755 | 0.78 | ALOX15 (0.46) | MMP8ALOX15CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL28521932 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL28694338 | 0.78 | ALOX15 (0.46) | MMP8ALOX15CYP4F2CYP4A11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080070868-A1 | Novel Thiazole Inhibitors of Fructose 1,6-bisphosphatase | METABASIS THERAPEUTICS, INC. (US) | 2008-03-20 | — | — | US | disclosed |
| US-20070225259-A1 | Novel Thiazole Inhibitors of Fructose 1,6-Bishosphatase | METABASIS THERAPEUTICS, INC. | 2007-09-27 | — | — | US | disclosed |
| EP-1778250-A2 | NOVEL THIAZOLE INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE | Metabasis Therapeutics, Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006023515-A2 | NOVEL THIAZOLE INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE | METABASIS THERAPEUTICS, INC. (US) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225259-A1 | Novel Thiazole Inhibitors of Fructose 1,6-Bishosphatase | FBP1, PFKFB1, ALDOA | MMP8 4379/4885ALOX15 3907/4885CYP4F2 321/4885 |
| US-20080070868-A1 | Novel Thiazole Inhibitors of Fructose 1,6-bisphosphatase | FBP1, ALDOA, SLC5A1 | MMP8 3687/4885ALOX15 2520/4885CYP4F2 225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.