Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HINT1 | P49773 | 2/20 | 0.43 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | HBB | P68871 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | ALB | P02768 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12724352 | 0.92 | LMNA (0.42) | LMNAHINT1MTORTHRBMDM2 | |
| SCHEMBL6315281 | 0.91 | ALB (0.41) | LMNAHINT1MTORTHRBMDM2 | |
| SCHEMBL11801230 | 0.90 | LMNA (0.45) | LMNAMTORTHRBGMNNALDH1A1 | |
| SCHEMBL2550066 | 0.88 | ADK (0.51) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL285586 | 0.85 | LMNA (0.46) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL26804271 | 0.85 | LMNA (0.51) | LMNATHRBALDH1A1TP53ALB | |
| SCHEMBL2583173 | 0.85 | LMNA (0.51) | LMNATHRBALDH1A1TP53ALB | |
| SCHEMBL3639989 | 0.85 | LMNA (0.51) | LMNATHRBALDH1A1TP53ALB | |
| SCHEMBL8670080 | 0.84 | IARS1 (0.45) | LMNAHINT1 | |
| SCHEMBL9849860 | 0.84 | ADK (0.45) | LMNAHINT1MTORTHRBMDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080145372-A1 | Bioreductively-Activated Prodrugs | ANGIOGENE, PHARMACEUTICALS LIMITED (GB) | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080145372-A1 | Bioreductively-Activated Prodrugs | NME2, PNP, NUDT1 | LMNA 1716/4885HINT1 29/4885MTOR 1926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.