Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.46 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27612735 | 0.84 | CA1 (0.54) | CA1CA2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL4955043 | 0.82 | CA1 (0.69) | CA1CA2TSHRHSD17B10LMNA | |
| SCHEMBL132175 | 0.82 | CA1 (0.69) | CA1CA2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL29769239 | 0.82 | CA1 (0.69) | CA1CA2TSHRHSD17B10LMNA | |
| SCHEMBL654794 | 0.81 | ALDH1A1 (0.52) | CA1CA2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL8906715 | 0.81 | CES2 (0.70) | CA1CA2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL10937456 | 0.81 | CES2 (0.57) | CA1CA2ALDH1A1TSHRKDM4E | |
| Hydrochloric Acid SCHEMBL7085459 | 0.80 | CA1 (0.67) | CA1CA2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL2956454 | 0.80 | CA1 (0.50) | CA1CA2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL1071711 | 0.80 | KDM4E (0.52) | CA1CA2ALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104402741-B | A kind of synthetic method of 2-hydroxyl-4-chloroaniline | Changzhou University (CN) | 2016-02-10 | — | — | CN | claimed |
| CN-104402741-A | Synthesis method of 2-hydroxy-4-chloroaniline | UNIV CHANGZHOU | 2015-03-11 | — | — | CN | claimed |
| CN-111138376-A | 3, 5-disubstituted phenyl-1, 2, 4-oxadiazole derivative and preparation method and application thereof | 中山大学 | 2020-05-12 | — | — | CN | disclosed |
| CN-103992336-B | Oxa-or thia evodiamine anti-tumor derivant and preparation method thereof | 中国人民解放军第二军医大学 | 2017-01-04 | — | — | CN | disclosed |
| CN-104402741-B | A kind of synthetic method of 2-hydroxyl-4-chloroaniline | Changzhou University (CN) | 2016-02-10 | — | — | CN | disclosed |
| CN-104402741-A | Synthesis method of 2-hydroxy-4-chloroaniline | UNIV CHANGZHOU | 2015-03-11 | — | — | CN | disclosed |
| CN-103992336-A | Oxa- or thio-evodiamine anti-tumor derivatives and preparation method thereof | UNIV PLA 2ND MILITARY MEDICAL | 2014-08-20 | — | — | CN | disclosed |
| US-8754107-B2 | Aminopyrrolidines as chemokine receptor antagonists | ABBVIE INC. (US) | 2014-06-17 | — | — | US | disclosed |
| CN-100475776-C | Amino acid diamides in non alpha position useful as adjuvants for the administration of active biological agents | ROVI LAB FARMACEUT SA (ES) | 2009-04-08 | — | — | CN | disclosed |
| US-7462735-B2 | Amino acid diamides in non α position which are useful as adjuvants for administration of biological active agents | LABORATORIOS FARMACEUTICOS ROVI, S.A. (ES) | 2008-12-09 | — | — | US | disclosed |
| US-20080176883-A1 | Antiinflammtory, antiproliferative, anticancer agents; (3-Hydroxy-pyrrolidin-1-yl)-(3-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-methanone | ABBVIE INC. | 2008-07-24 | — | — | US | disclosed |
| EP-1652836-A1 | AMINO ACID DIAMIDES IN NON ALPHA POSITION USEFUL AS ADJUVANTS FOR THE ADMINISTRATION OF ACTIVE BIOLOGICAL AGENTS | LABORATORIOS FARMACEUTICOS ROVI, S.A. (ES) | 2006-05-03 | — | — | EP | disclosed |
| US-20030171422-A1 | New nitromethyl ketones, process for preparing them and compositions containing them | MERCK PATENT GMBH (DE) | 2003-09-11 | — | — | US | disclosed |
| US-6559185-B2 | Nitromethyl ketone compounds having aldose reduction inhibiting properties and methods for their use | MERCK PATENT GMBH (DE) | 2003-05-06 | — | — | US | disclosed |
| US-20030069312-A1 | Antidiabetic agents | LARDY CLAUDE (FR) | 2003-04-10 | — | — | US | disclosed |
| CN-1257474-A | New nitromethylketone compounds, process for their preparation and compositions containing them | MERCK PATENT GMBH (DE) | 2000-06-21 | — | — | CN | disclosed |
| US-6043281-A | ALDOSE REDUCTASE INHIBITORS; TREATMENT OR PREVENTION OF COMPLICATIONS OF DIABETES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-28 | — | — | US | disclosed |
| EP-0983226-A1 | NEW NITROMETHYL KETONES, PROCESS FOR PREPARING THEM AND COMPOSITIONS CONTAINING THEM | MERCK PATENT GmbH (DE) | 2000-03-08 | — | — | EP | disclosed |
| US-5932765-A | REDUCTASE INHIBITORS | MERCK PATENT GESELLSCHAFT MIT (DE) | 1999-08-03 | — | — | US | disclosed |
| WO-1998052906-A1 | NEW NITROMETHYL KETONES, PROCESS FOR PREPARING THEM AND COMPOSITIONS CONTAINING THEM | MERCK PATENT GMBH (DE) | 1998-11-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176883-A1 | Antiinflammtory, antiproliferative, anticancer agents; (3-Hydroxy-pyrrolidin-1-yl)-(3-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-methanone | MIF, CCL5, CCR2 | CA1 4706/4885CA2 4436/4885ALDH1A1 433/4885 |
| US-20030069312-A1 | Antidiabetic agents | SLC5A1, SLC5A2, GPR119 | CA1 4446/4885CA2 3386/4885ALDH1A1 33/4885 |
| US-20030171422-A1 | New nitromethyl ketones, process for preparing them and compositions containing them | AKR1B1, AKR1A1, AKR1C1 | CA1 4451/4885CA2 4444/4885ALDH1A1 63/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.