Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 8/20 | 0.53 |
| ▸ | PPARA | Q07869 | 6/20 | 0.53 |
| ▸ | PPARD | Q03181 | 3/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.51 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | LAP3 | P28838 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4891449 | 0.94 | FFAR1 (0.56) | PPARGPPARAPPARDFFAR1FFAR4 | |
| SCHEMBL9615672 | 0.82 | HSD17B10 (0.57) | PPARG | |
| SCHEMBL9615760 | 0.76 | PPARG (0.51) | PPARGPPARA | |
| SCHEMBL14210013 | 0.70 | PPARA (0.68) | PPARGPPARAPPARDFFAR1FFAR4 | |
| SCHEMBL891493 | 0.70 | FFAR1 (0.69) | PPARGFFAR1FFAR4HRH3LTA4H | |
| SCHEMBL4481252 | 0.69 | ALDH1A1 (0.74) | PPARGPPARAPPARD | |
| SCHEMBL13919544 | 0.69 | ALDH1A1 (0.74) | PPARGPPARAPPARD | |
| SCHEMBL7801265 | 0.69 | PPARA (0.70) | PPARGPPARAPPARDFFAR1FFAR4 | |
| SCHEMBL1744943 | 0.69 | FFAR1 (1.00) | FFAR1FFAR4 | |
| SCHEMBL1747130 | 0.69 | FFAR1 (1.00) | FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893582-A2 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USE IN TREATING METABOLIC DISORDERS | Amgen, Inc (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006127503-A2 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USE IN TREATING METABOLIC DISORDERS | AMGEN INC (US) | 2006-11-30 | — | — | WO | disclosed |