Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | GFER | P55789 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17136360 | 0.80 | HDAC3 (0.48) | SMN1; SMN2KMT2AALDH1A1TDP1MAPT | |
| SCHEMBL5178524 | 0.78 | RAB9A (0.50) | SMN1; SMN2KMT2AALDH1A1NPSR1MAPT | |
| SCHEMBL9298064 | 0.77 | FPR2 (0.50) | KMT2AALDH1A1NPSR1MAPTALOX15 | |
| SCHEMBL5178520 | 0.77 | NPSR1 (0.47) | SMN1; SMN2KMT2AALDH1A1NPSR1MAPT | |
| SCHEMBL8275731 | 0.77 | NPC1 (0.46) | SMN1; SMN2KMT2AALDH1A1NPSR1MAPT | |
| Hydrochloric Acid SCHEMBL27651177 | 0.76 | ALDH1A1 (0.47) | SMN1; SMN2KMT2AALDH1A1TDP1MAPT | |
| SCHEMBL13634357 | 0.75 | L3MBTL1 (0.54) | KMT2AALDH1A1NPSR1MAPTALOX15 | |
| SCHEMBL8275413 | 0.75 | NPSR1 (0.47) | SMN1; SMN2KMT2AALDH1A1NPSR1MAPT | |
| SCHEMBL22876069 | 0.74 | NPSR1 (0.45) | KMT2AALDH1A1NPSR1MAPTALOX15 | |
| Hydrochloric Acid SCHEMBL4886963 | 0.74 | NPSR1 (0.46) | SMN1; SMN2KMT2AALDH1A1TDP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080015202-A1 | Thiazole Derivatives Having Vap-1 Inhibitory Activity | ASTELLAS PHARMA INC. (JP) | 2008-01-17 | — | — | US | disclosed |
| EP-1791835-A2 | THIAZOLE DERIVATIVES HAVING VAP-1 INHIBITORY ACTIVITY | Astellas Pharma Inc. (JP) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006028269-A2 | THIAZOLE DERIVATIVES HAVING VAP-1 IHIBITORY ACTIVITY | ASTELLAS PHARMA INC. (JP) | 2006-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015202-A1 | Thiazole Derivatives Having Vap-1 Inhibitory Activity | VCAM1, VAPB, VAPA | SMN1; SMN2 2277/4885KMT2A 4199/4885ALDH1A1 1877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.