Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.39 |
| ▸ | HTR3B | O95264 | 5/20 | 0.39 |
| ▸ | HTR3A | P46098 | 5/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14896676 | 0.81 | ALOX5 (0.46) | ALOX5MMP2MMP9MMP8MMP13 | |
| SCHEMBL14897578 | 0.81 | ALOX5 (0.46) | ALOX5MMP2MMP9MMP8MMP13 | |
| SCHEMBL31195791 | 0.79 | HSD17B14 (0.47) | ALOX5DRD2DRD3MAPTHTR3E | |
| SCHEMBL12633158 | 0.79 | PIM1 (0.40) | PIM1PIM2HTR3EHTR3BHTR3A | |
| SCHEMBL30454486 | 0.79 | GRIN2D (0.59) | ALOX5DRD2DRD3PIM1PIM2 | |
| SCHEMBL12804690 | 0.79 | GRIN2D (0.59) | ALOX5DRD2DRD3PIM1PIM2 | |
| SCHEMBL29393407 | 0.77 | ALOX5 (0.44) | ALOX5MMP2MMP9MMP8MMP13 | |
| SCHEMBL2371248 | 0.76 | GAA (0.51) | ALOX5DRD2DRD3PIM1MAPT | |
| SCHEMBL30818693 | 0.76 | GAA (0.51) | ALOX5DRD2DRD3PIM1MAPT | |
| SCHEMBL3632004 | 0.76 | HTR3E (0.64) | ALOX5HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8754107-B2 | Aminopyrrolidines as chemokine receptor antagonists | ABBVIE INC. (US) | 2014-06-17 | — | — | US | disclosed |
| US-20080176883-A1 | Antiinflammtory, antiproliferative, anticancer agents; (3-Hydroxy-pyrrolidin-1-yl)-(3-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-methanone | ABBVIE INC. | 2008-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176883-A1 | Antiinflammtory, antiproliferative, anticancer agents; (3-Hydroxy-pyrrolidin-1-yl)-(3-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-methanone | MIF, CCL5, CCR2 | ALOX5 308/4885MMP2 1617/4885MMP9 844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.