Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424308 | 0.91 | ALDH1A1 (0.38) | ABCB11KDM4ECYP2C9MEN1KMT2A | |
| SCHEMBL7418565 | 0.87 | CYP2C9 (0.33) | ABCB11KDM4ECYP2C9MEN1KMT2A | |
| SCHEMBL2365028 | 0.83 | TSHR (0.37) | ABCB11KDM4ECYP2C9MEN1KMT2A | |
| SCHEMBL3393583 | 0.76 | TSHR (0.40) | KDM4ECYP2C9MEN1KMT2ALMNA | |
| SCHEMBL4758577 | 0.70 | TSHR (0.36) | ABCB11KDM4ECYP2C9MEN1KMT2A | |
| SCHEMBL9101372 | 0.66 | TSHR (0.37) | ABCB11KDM4ECYP2C9MEN1KMT2A | |
| SCHEMBL9033489 | 0.66 | CYP2C9 (0.31) | ABCB11KDM4ECYP2C9MEN1KMT2A | |
| SCHEMBL4758043 | 0.66 | CRHBP (0.40) | KDM4ECYP2C9MEN1KMT2ALMNA | |
| SCHEMBL30516327 | 0.65 | PYGL (0.34) | ABCB11ABCB1ADORA3ADRB3TBXA2R | |
| SCHEMBL7210502 | 0.65 | ABCB11 (0.64) | ABCB11KDM4ECYP2C9MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080095841-A1 | Pharmaceutical Composition, Method for Producing the Same, and Method for Stabilizing Dihydropyridine Compound in the Pharmaceutical Composition | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-04-24 | — | — | US | disclosed |
| EP-1813274-A1 | MEDICINAL COMPOSITION, PROCESS FOR PRODUCING THE SAME, AND METHOD OF STABILIZING DIHYDROPYRIDINE COMPOUND IN MEDICINAL COMPOSITION | Eisai R&D Management Co., Ltd. (JP) | 2007-08-01 | — | — | EP | disclosed |
| EP-1133473-A1 | NEW MANUFACTURING PROCESS | AstraZeneca AB (SE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000031035-A1 | NEW MANUFACTURING PROCESS | ASTRAZENECA AB (SE) | 2000-06-02 | — | — | WO | disclosed |