SCHEMBL7424308

SCHEMBL7424308

CCC(=O)OCN1C(C)=C(C(=O)O)C(C)(c2cccc(Cl)c2Cl)C(C(=O)O)=C1C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.38
CYP1A2 P05177 3/20 0.38
CYP2C19 P33261 3/20 0.38
HIF1A Q16665 3/20 0.38
HPGD P15428 2/20 0.38
BLM P54132 2/20 0.38
WRN Q14191 1/20 0.38
MEN1 O00255 4/20 0.34
KMT2A Q03164 4/20 0.34
CYP2C9 P11712 3/20 0.34
LMNA P02545 3/20 0.34
KDM4E B2RXH2 2/20 0.34
CYP3A4 P08684 2/20 0.34
HSD17B10 Q99714 2/20 0.34
ABCB11 O95342 2/20 0.34
TSHR P16473 2/20 0.34
MAPT P10636 2/20 0.34
TP53 P04637 1/20 0.34
CYP2D6 P10635 1/20 0.34
NFKB1 P19838 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4884972 0.91 ABCB11 (0.42) ALDH1A1CYP1A2CYP2C19HIF1AHPGD
SCHEMBL7418565 0.89 CYP2C9 (0.33) ALDH1A1CYP1A2CYP2C19HIF1AHPGD
SCHEMBL2365028 0.85 TSHR (0.37) ALDH1A1CYP1A2CYP2C19HIF1AHPGD
SCHEMBL3393583 0.78 TSHR (0.40) ALDH1A1CYP1A2CYP2C19HIF1AHPGD
SCHEMBL4758577 0.72 TSHR (0.36) ALDH1A1CYP1A2CYP2C19HIF1AHPGD
SCHEMBL9101372 0.68 TSHR (0.37) ALDH1A1CYP1A2CYP2C19HIF1AHPGD
SCHEMBL9033489 0.68 CYP2C9 (0.31) ALDH1A1CYP1A2CYP2C19HIF1AHPGD
SCHEMBL4758043 0.68 CRHBP (0.40) ALDH1A1CYP1A2CYP2C19HIF1AHPGD
SCHEMBL30516327 0.67 PYGL (0.34) ABCB11ABCB1ADORA3ADRB3TBXA2R
SCHEMBL30656597 0.66 HTR1A (0.39) CYP3A4ABCB11NR1I2ABCB1ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0727997-A1 PHARMACEUTICAL EMULSION Astra Aktiebolag (SE) 1996-08-28 EP claimed
WO-1995013066-A1 PHARMACEUTICAL EMULSION ASTRA AKTIEBOLAG (SE) 1995-05-18 WO claimed